Прегледај по Аутор "Maric, Helena"

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    PERIODONTAL DISEASE: CORRELATION WITH HISTOLOGICAL AND IMMUNOLOGICAL PARAMETERS
    (2023) Kujundzic, Bojan; Andjelkovic, Zlatibor; Maric, Radmila; Lukic, Ruzica; Maric, Veljko; Maric, Helena; Obrenovic, Miroslav; Kojic, Sinisa
    Periodontal disease is inflammatory pathological conditions in the gingiva and dental support structures that usually results in extracellular matrix and connective tissue destruction. During periodontitis, inflammatory cells facilitate collagen and connective tissue loss, affects the number and activity of fibroblasts and its production of local collagen networks. Aim of this study was to evaluate collagen density and accumulation of collagen producing fibroblast and macrophages in affected tissue of periodontal disease. Histological and immunohistochemical analyzes were performed on paraffin embedded tissue sections of gingival biopsies, obtained from 30 patients with diagnosis of periodontal disease and 10 healthy donors. Tissue sections of gingival of patients with periodontal disease had significantly decreased collagen volume density and visible fragmentation and lysis of the collagen fibers, decreased number of fibroblasts, accompanied with increased accumulation of macrophages. Presented data implicate that macrophages accumulation may be the cause of enzyme mediated collagen destruction.
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    POSSIBILITY OF OPERATIVE TREATMENT OF UTERINE SARCOMA: CASE REPORT
    (Sciendo, 2019) Ivanovic, Radenko; Maric, Helena; Cancar, Vladimir; Nikolic, Dragana; Lecic, Radislavka; Arsenovic, Milan
    Uterine sarcomas make up only 5% of all malignancies in gynecology. Th eir classifi cation is complicated due to low incidence and large histological diff erences. Uterine sarcoma is usually diagnosed in postmenopausal women, and this is most often done accidentally at the postoperative stage. The existence of uterine sarcoma should be suspected in cases of rapid uterine growth in postmenopausal state. Postmenopausal abnormal bleeding is the most common reason for a medical examination. In this paper, a 48-year-old patient is presented in whose case during a regular gynecological examination; the existence of tumour change in the uterine part of uterus has been noticed. Th e patient did not have gynecological problems until then. The patient was then subjected to a diagnostic exploratory curettage. The pathohistological fi nding was negative. Given that the onset change is present after the control check, it is decided to proceed with an operative procedure. A pathohistological fi nding (uterus and adnexa) indicates that it is a uterine sarcoma. After that, the patient was re-treated with two more operations and then had chemotherapy and radiation therapy. After completing the whole treatment, for the period of six years, the patient now feels well and performs her usual work tasks.