Прегледај по Аутор "Obrenovic, Miroslav"
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- СтавкаDENTAL FOCAL INFECTIONS AND ALOPECIA AREATA(Serbian Medical Association Kragujevac district branch, 2015) Regoje, Dobrila; Golijanin, Ranko; Pinjic, Omer; Obrenovic, Miroslav; Kujundzic, BojanObjective. The aim of this study was to examine the association of dental focal infections and alopecia areata in the adult population. Methods. The research was done in a medical institution, “Dermato-dento-medik Brcko dr Regoje”, and the Clinic for Dermatovenerology of University Clinical Center, Tuzla. The study included 63 patients which were treated surgically and medically according to the current therapeutic guidelines. All patients were divided into three groups. The first group of patients suffering from alopecia areata were treated only surgically, by removing the focus. In the second group there were patients who were treated by removing the focus and local dermatological therapy (most of them had periodontal disease). In the third group there were patients who were treated only with local dermatological therapy (most of them had gingival hyperplasia). Results. In total of 41 subjects the changes of alopecia areata had affected the hairy part, while 22 patients had changes on the chin. The difference in distribution, in relation to the expected even distribution, was statistically significant (2=5.7, df=1, p=0.017). However, the difference concerning the observed distribution of lesion in hairy parts and in other location between the three study groups was not statistically significant (2=0.2, df=1, p=0.676). Analysis of the outcomes of treatment for alopecia areata showed the highest effectiveness in the second group (n=21) because the hair growth appeared after 4 to 6 weeks after the initiation of the therapy. In the first group (n=20) the hair growth appeared within 6 to 8 weeks, and in the third group there was no hair growth during the monitoring period up to 8 weeks. Conclusion. Our study present novel data about relationships between dental focal infections and alopecia areata with outcomes after surgical and medical treatment, respectively.
- СтавкаPERIODONTAL DISEASE: CORRELATION WITH HISTOLOGICAL AND IMMUNOLOGICAL PARAMETERS(2023) Kujundzic, Bojan; Andjelkovic, Zlatibor; Maric, Radmila; Lukic, Ruzica; Maric, Veljko; Maric, Helena; Obrenovic, Miroslav; Kojic, SinisaPeriodontal disease is inflammatory pathological conditions in the gingiva and dental support structures that usually results in extracellular matrix and connective tissue destruction. During periodontitis, inflammatory cells facilitate collagen and connective tissue loss, affects the number and activity of fibroblasts and its production of local collagen networks. Aim of this study was to evaluate collagen density and accumulation of collagen producing fibroblast and macrophages in affected tissue of periodontal disease. Histological and immunohistochemical analyzes were performed on paraffin embedded tissue sections of gingival biopsies, obtained from 30 patients with diagnosis of periodontal disease and 10 healthy donors. Tissue sections of gingival of patients with periodontal disease had significantly decreased collagen volume density and visible fragmentation and lysis of the collagen fibers, decreased number of fibroblasts, accompanied with increased accumulation of macrophages. Presented data implicate that macrophages accumulation may be the cause of enzyme mediated collagen destruction.