Clinical antibacterial effectiveness and biocompatibility of gaseous ozone after incomplete caries removal

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dc.citation.epage792
dc.citation.spage785
dc.citation.volume23
dc.contributor.authorKrunić, Jelena
dc.contributor.authorStojanović, Nikola
dc.contributor.authorĐukić, Ljiljana
dc.contributor.authorRoganović, Jelena
dc.contributor.authorPopović, Branka
dc.contributor.authorSimić, Ivana
dc.contributor.authorStojić, Dragica
dc.date.accessioned2023-04-18T20:54:02Z
dc.date.available2023-04-18T20:54:02Z
dc.date.issued2019
dc.description.abstractObjectives To evaluate local effect of gaseous ozone on bacteria in deep carious lesions after incomplete caries removal, using chlorhexidine as control, and to investigate its effect on pulp vascular endothelial growth factor (VEGF), neuronal nitric oxide synthase (nNOS), and superoxide dismutase (SOD). Materials and methods Antibacterial effect was evaluated in 48 teeth with diagnosed deep carious lesion. After incomplete caries removal, teeth were randomly allocated into two groups regarding the cavity disinfectant used: ozone (open system) or 2% chlorhexidine. Dentin samples were analyzed for the presence of total bacteria and Lactobacillus spp. by real-time quantitative polymerase chain reaction. For evaluation of ozone effect on dental pulp, 38 intact permanent teeth indicated for pulp removal/ tooth extraction were included. After cavity preparation, teeth were randomly allocated into two groups: ozone group and control group. VEGF/nNOS level and SOD activity in dental pulp were determined by enzyme-linked immunosorbent assay and spectrophotometric method, respectively. Results Ozone application decreased number of total bacteria (p = 0.001) and Lactobacillus spp. (p < 0.001), similarly to chlorhexidine. The VEGF (p < 0.001) and nNOS (p = 0.012) levels in dental pulp after ozone application were higher, while SOD activity was lower (p = 0.001) comparing to those in control pulp. Conclusions Antibacterial effect of ozone on residual bacteria after incomplete caries removal was similar to that of 2% chlorhexidine. Effect of ozone on pulp VEGF, nNOS, and SOD indicated its biocompatibility. Clinical relevance Ozone appears as effective and biocompatible cavity disinfectant in treatment of deep carious lesions by incomplete caries removal technique.
dc.identifier.doi10.1007/s00784-018-2495-x
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/101
dc.language.isoen
dc.publisherSpringer
dc.sourceClinical Oral Investigations
dc.subjectOzone, Incomplete caries removal, Antibacterial effect, Residual caries, Biocompatibility
dc.titleClinical antibacterial effectiveness and biocompatibility of gaseous ozone after incomplete caries removal
dc.typeArticle
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Медицински факултет [Научни радови] / Faculty of Medicine [Scientific papers]