POTASSIUM CHANNELS OPENER PINACIDIL HAVE MULTIPLE EFFECTS ON KCl-ELICITED CONTRACTIONS OF ISOLATED NON-PREGNANT RAT UTERUS

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dc.citation.epage140
dc.citation.spage133
dc.citation.volume61
dc.contributor.authorNOVAKOVIĆ, RADMILA
dc.contributor.authorMILOVANOVIĆ, S.
dc.contributor.authorĆUPIĆ, V.
dc.contributor.authorGOJKOVIĆ-BUKARICA, LJILJANA
dc.date.accessioned2023-09-14T11:01:02Z
dc.date.available2023-09-14T11:01:02Z
dc.date.issued2011
dc.description.abstractThe effects of K+ channel opener, pinacidil on contractions provoked by contraction-stimulating KCl were investigated on isolated uterus of non-pregnant rats in oestrus. Pinacidil produced a more potent inhibition of 20 mM KCl–elicited contractions (pD2 = 6.57 M) than of 40 or 80mMKCl–elicited contractions (pD2=5.11 and 5.19 M, respectively). Glibenclamide, a selective blocker of adenosine triphosphate (ATP)-sensitive K+ (KATP) channels, antagonized the pinacidil-induced inhibition of contractions elicited by 20 mM KCl in a competitive manner. However, the pinacidil-induced inhibition of contractions provoked by 40 and 80 mM KCl glibenclamide was unable to prevent them. Pinacidil ability to completely relax the non-pregnant uterus pre-contracted with K+-rich solution suggests that K+ channelindependent mechanism(s) also plays a part in its relaxant effect.
dc.identifier.doi10.2298/AVB1103133N
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/765
dc.language.isoen
dc.publisherUniversity of Belgrade - Faculty of Veterinary Medicine, Belgrade
dc.sourceActa Veterinaria (Beograd)
dc.subjecthigh K+ solution, KATP channels, pinacidil, rat uterus
dc.titlePOTASSIUM CHANNELS OPENER PINACIDIL HAVE MULTIPLE EFFECTS ON KCl-ELICITED CONTRACTIONS OF ISOLATED NON-PREGNANT RAT UTERUS
dc.typeArticle
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