MODULATORY ROLE OF GALECTIN-1 IN ULCERATIVE COLITIS WITH COMORBID METABOLIC SYNDROME

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dc.contributor.authorCorovic, Kemal
dc.contributor.authorStojanovic, Bojan
dc.contributor.authorPetrovic, Andjela
dc.contributor.authorStanisavljevic, Isidora
dc.contributor.authorMaric, Veljko
dc.contributor.authorZdravkovic, Natasa
dc.contributor.authorJovanovic, Marina
dc.date.accessioned2024-12-18T12:43:59Z
dc.date.available2024-12-18T12:43:59Z
dc.date.issued2023
dc.description.abstractMetabolic syndrome (MetS) and ulcerative colitis (UC) are widespread health conditions characterized by chronic, low-grade inflammation. Galectin-1 (Gal-1), an immunomodulatory peptide mainly secreted from adipose tissue, could potentially play a crucial role in mitigating these conditions. This cross-sectional study explores the involvement of Gal-1 in MetS and UC within a cohort of 75 patients, newly diagnosed with UC. The MetS subgroup displayed increased fecal Gal-1 levels compared to those without MetS. Furthermore, Gal-1 showed predominance over pro-inflammatory cytokines, including TNF-α, IL-6, and IL-17, in these subjects. These findings emphasize the potential involvement of Gal-1 in the pathophysiology of UC and MetS, presenting it as a promising diagnostic biomarker and therapeutic target for these conditions.
dc.identifier.doi10.2478/eabr-2023-0006
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/1413
dc.language.isoen
dc.publisherDe Gruyter
dc.sourceSciendo
dc.subjectGalectin-1, Ulcerative Colitis, Metabolic Syndrome, Inflammation
dc.titleMODULATORY ROLE OF GALECTIN-1 IN ULCERATIVE COLITIS WITH COMORBID METABOLIC SYNDROME
dc.typeArticle
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