Diethyldithiocarbamate potentiates the effects of protamine sulphate in the isolated rat uterus

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dc.citation.epage54
dc.citation.spage48
dc.citation.volume14
dc.contributor.authorOreščanin-Dusić, Zorana
dc.contributor.authorMilovanović, Slobodan
dc.contributor.authorBlagojević, Duško
dc.contributor.authorNikolić-Kokić, Aleksandra
dc.contributor.authorRadojičić, Ratko
dc.contributor.authorSpasojević, Ivan
dc.contributor.authorSpasić, Mihajlo
dc.date.accessioned2023-09-18T10:17:28Z
dc.date.available2023-09-18T10:17:28Z
dc.date.issued2009
dc.description.abstractProtamine sulphate causes potassium ion channel-mediated relaxation of spontaneous and calcium ion-induced contractions of the isolated rat uterus. Diethyldithiocarbamate (DDC) potentiated the effect of protamine sulphate. A mechanism for DDC’s action was postulated on the basis of its interactions with divalent iron ions and Cu,Zn-SOD. DDC chelates divalent iron ions creating DDC-iron (Fe-DDC) complexes. Fe-DDC forms stable NO-Fe-DDC2 complexes by NO scavenging and de-nitrosylation processes, which in combination with DDC (5 mM) provoke inhibition of Cu,Zn-SOD resulting in specific oxidative conditions culminating in potassium ion channel opening, membrane hyperpolarisation, inhibition of calcium ion influx and subsequent muscle relaxation. As Fe-DDC and NO-Fe-DDC2 complexes exclude divalent iron ions from participating in the hydroxyl radical generating Fenton reaction, DDC can also prevent iron-related pathophysiological manifestations. Such permissive roles of DDC open the possibility for application of its pharmacological form (disulfiram) to a wider spectrum of pathophysiological conditions related to smooth muscles.
dc.identifier.doi10.1179/135100009X392476
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/789
dc.language.isoen
dc.publisherTaylor & Francis
dc.sourceRedox Report
dc.subjectprotamine sulphate, diethyldithiocarbamate, uterus, nitric oxide
dc.titleDiethyldithiocarbamate potentiates the effects of protamine sulphate in the isolated rat uterus
dc.typeArticle
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