Lymphocyte Subsets in Bronchoalveolar Lavage Fluid of Children with Lung Infiltrates

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dc.citation.epage144
dc.citation.spage139
dc.citation.volume29
dc.contributor.authorSelimović, Amina
dc.contributor.authorMesihović Dinarević, Senka
dc.contributor.authorPejčić, Tatjana
dc.contributor.authorMujičić, Ermina
dc.contributor.authorHasanović, Aida
dc.contributor.authorRistić, Siniša
dc.contributor.authorBanjac, Nataša
dc.contributor.authorPavlović, Željko
dc.date.accessioned2023-09-13T07:02:17Z
dc.date.available2023-09-13T07:02:17Z
dc.date.issued2012
dc.description.abstractThe analysis of the subpopulation of lymphocytes - CD4+, CD8+ lymphocytes in bronchoalveolar lavage (BAL) of paediatric patients can provide useful information related the lung parenchyma. The aim of the paper was to analyze the results of bronchoscopy of patients presenting with persistent lung infiltrates and to find out of the diagnostic yield and complication rate of this procedure. The study is a retrospective one. The data related to paediatric findings and BAL results of the bronchoscopies were retrieved from the hospital records. BAL was performed in tracheobronchial airways (middle lobe) by bronchoscope and sent to analysis of CD4+, CD8+ lymphocytes. Bronchoscopy was performed under general anesthesia (sedation, propofol, midazolam, morphium). The records of seven patients were analyzed. All patients presented with persistent lung infiltrate (atelectasis and pneumonia). 71% of the patients with lung infiltrates in our study were below the age of 5. Our study results showed that CD4+, CD8+ lymphocytes in BAL in the studied group showed a small percentage of CD8+ lymphocytes as an immune response in 8-10% of patients, while the cellular response of CD4 +lymphocytes in the sample itself was present up to 14% in the entire group of the diseased children. There was no serious desaturation during bronchoscopy. Bronchoscopy with BAL findings of lymphocyte populations is important in the early identification of inflammation and it helps in therapeutic strategies and monitoring of inflammatory response to the given therapy.
dc.identifier.doi10.2478/v10283-012-0019-1
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/745
dc.language.isoen
dc.publisherUniversity of Nis, Faculty of Medicine, Serbia
dc.sourceActa Facultatis Medicae Naissensis
dc.subjectflexible bronchoscopy with BAL, CD4+, CD8+ lymphocyte, lung infiltrate
dc.titleLymphocyte Subsets in Bronchoalveolar Lavage Fluid of Children with Lung Infiltrates
dc.typeArticle
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