Дигитални репозиторијум ВАСЕЉЕНА
Дигитални репозиторијум ВАСЕЉЕНА је заједнички репозиторијум свих чланица Универзитета у Источном Сарајеву.
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Analysis of Power Losses in Constrained Cycloid Drive
(Strojarski Facultet, Sveucilist Joseph Jurj Strossmayer in Osijeka, 2023) MAČKIĆ, Tihomir; MARJANOVIĆ, Nenad; TICA, Milan; TROHA, Sanjin; MILUTINOVIĆ, Miroslav; RAŠOVIĆ, Nebojša
The aim of this paper is to present a theoretical model for efficiency evaluation of a simple cycloid drive train with one degree of freedom (DOF) or constrained cycloid drive. In order to evaluate the efficiency, it is necessary to find the losses generated in the simple cycloid drive, where only losses depending on the load were considered. Expressions for determining speed ratios, efficiency, velocities and forces acting inside the cycloid drive are presented. These expressions are implemented in the theoretical model, where the places where the losses occur are defined. A computer program was created to facilitate analysis and obtain loss values based on different input data. Only load-dependent losses were considered in the theoretical model and computer program. In order to verify the theoretical model, experimental measurements were performed. A physical model of the simple cycloid drive train was created and analyzed on the test bench. The results for "S1" operating mode, i.e. when shaft 2 is stopped, show a mean value of the efficiency of 63.49%, for experimental measurements, while the mean value for theoretical analysis is 65.25%. For the operating mode "S2", i.e. with shaft 1 stopped, the mean value of the experimental measurements of the efficiency is 60.9%, while the theoretical mean value is 62.82%.
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THE DEVELOPMENT OF A NEW SOFI MODEL FOR PERFORMANCE MANAGEMENT OF MEDIUM SIZED AND LARGE COMPANIES
(Regional Association for Security and crisis management, 2023) Kovačević, Biljana
Measurement and adequate performance management of a company represent an imperative regarding the attainment of competitive advantage in the market. This need is especially pronounced in medium-sized and large companies, which represent complex organizations and require the application of scientific principles for solving complex issues in practice. Therefore, the performance management process in medium-sized and large companies is singled out as the subject of the research. It is important to point out that the main concept of the paper is the macro aspect of the performance management process. The primary goal of the research is the development of a new model for performance management based on considering all important parameters of business operations of these companies on the territory of the Republic of Srpska. The research was conducted via combined methods – a multiple case study which implies four companies and a survey questionnaire. Through the analysis of many models in the literature, seven were singled out which were studied further. The main elements and conceptual bases of these models served as the basis for conducting research and creating a new model for performance management. The result of the published research represents “SOFI” model (strategic, organizational, financial and information–technological aspects), whose application contributes towards easier management by managers, as well as making correct management decisions in the conditions of uncertainty.
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Sitagliptin Induces Tolerogenic Human Dendritic Cells
(MDPI, 2023) Drakul, Marija; Tomić, Sergej; Bekić, Marina; Mihajlović, Dušan; Vasiljević, Miloš; Rakočević, Sara; Ðokić, Jelena; Popović, Nikola; Bokonjić, Dejan; Čolić, Miodrag
Sitagliptin, an anti-diabetic drug, is a dipeptidyl peptidase (DPP)-4/CD26 inhibitor with additional anti-inflammatory and immunomodulatory properties. In this study, we investigated for the first time the effect of sitagliptin on the differentiation and functions of human dendritic cells generated from monocytes (MoDCs) for 4 days using the standard GM-CSF/IL-4 procedure. LPS/IFN-y treatment for an additional 24 h was used for maturation induction of MoDCs. Sitagliptin was added at the highest non-cytotoxic concentration (500 g/mL) either at the beginning (sita 0d protocol) or after MoDC differentiation (sita 4d protocol). Sitagliptin impaired differentiation and maturation of MoDCs as judged with the lower expression of CD40, CD83, CD86, NLRP3, and HLA-DR, retention of CD14 expression, and inhibited production of IL- , IL-12p70, IL-23, and IL-27. In contrast, the expression of CD26, tolerogenic DC markers (ILT4 and IDO1), and production of immunoregulatory cytokines (IL-10 and TGF- ) were increased. Generally, the sita 0d protocol was more efficient. Sitagliptin-treated MoDCs were poorer allostimulators of T-cells in MoDC/T-cell co-culture and inhibited Th1 and Th17 but augmented Th2 and Treg responses. Tolerogenic properties of sitagliptin-treated MoDCs were additionally confirmed by an increased frequency of CD4+CD25+CD127- FoxP3+ Tregs and Tr1 cells (CD4+IL-10+FoxP3-) in MoDC/T-cell co-culture. The differentiation of IL-10+ and TGF- + Tregs depended on the sitagliptin protocol used. A Western blot analysis showed that sitagliptin inhibited p65 expression of NF-kB and p38MAPK during the maturation of MoDCs. In conclusion, sitagliptin induces differentiation of tolerogenic DCs, and the effect is important when considering sitagliptin for treating autoimmune diseases and allotransplant rejection.
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Comparison of the Bacterial Inactivation Efficiency ofWater Activated by a Plasma Jet Source and a Pin-to-Pin Electrode Configuration Source
(MDPI, 2023) Čobanović, Radovan; Maletić, Dejan; Kocić-Tanackov, Sunčica; Čabarkapa, Ivana; Kokić, Bojana; Kojić, Predrag; Milošević, Slobodan; Stulić, Višnja; Vukušić Pavičić, Tomislava; Vukić, Milan
In this comparative study, the bacterial inactivation efficiency of plasma-activated water (PAW) generated by two distinct plasma reactors, one utilizing a nitrogen plasma jet electrode and the other a hybrid argon plasma reactor, was explored. The present study involved the assessment of antimicrobial activity against suspensions of three Gram-positive and three Gram-negative bacterial strains in their planktonic cell state. Bacterial suspensions were introduced into PAW five days after generation. Subsequently, the viability of the bacteria was assessed at various time intervals,
specifically at 0.5, 1, 3, 5, 10, and 24 h, in order to evaluate the effect of inactivation. Structural changes in bacteria after PAW treatment were assessed using a scanning electron microscope (SEM). The physicochemical properties of PAW, including pH, conductivity, and concentrations of H2O2, NO2 -, and NO3 - during aging were measured. The present study demonstrated the effective inactivation of the tested bacterial strains by PAW. Gram-positive bacteria displayed greater resistance compared to Gram-negative species, with the lowest reductions in bacterial counts observed for B. cereus, and the highest for Escherichia coli O157:H7. Morphological damage was evident across all bacterial species examined. Physicochemical measurements showed slow decay of the reactive species in the aging process. This study illustrated the potential utility of PAW as an alternative disinfectant.
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Development of a disaster mitigation learning program for kindergarten students through physical fun games
(Editura Universitatii din Pitesti, 2023) PRANOTO, NURIDIN WIDYA; SIBOMANA, ALEXANDRE; NDAYISENGA, JAPHET; CHAERONI, AHMAD; FAUZIAH, VARHATUN; SUSANTO, NUGROHO; PAVLOVIC, RATKO; RAYENDRA, RAYENDRA
Children are the most vulnerable group when natural disasters occur, but few children have the
knowledge to save themselves when a disaster occurs. The lack or even ignorance of the actions that need to be taken when a disaster occurs is the cause of the high number of child victims during natural disasters. This research aims to develop and validate a natural disaster mitigation games program that can increase children's knowledge of natural disaster preparedness.
Methods: 140 students were involved in testing research products. The method used in this research is research & development with 10 stages. Validity analysis of item suitability through Aiken v which was processed using Microsoft Excel. Reliability data was analyzed using SPSS 20.
Results: Natural disaster mitigation learning products were produced which were conceptualized through 7 fun disaster mitigation games consisting of games for earthquakes, volcanic eruptions, tsunamis, floods, landslides, tornadoes, forest fires. The results of this research obtained optimal content validity values (Aiken V = 0.81). Average internal validation value (r=0.81). The reliability value was obtained using Cronbach's Alpha with a value of 1.0. From the test results, it was concluded that the disaster mitigation learning program for kindergarten students through fun physical disaster games was valid and reliable. Conclusions: The findings show that the disaster mitigation learning program through physical fun games mitigation has proven to be valid and reliable for use in teaching kindergarten student natural disaster mitigation material. Through learning physical fun mitigation games, children are more active in understanding the concept of disaster mitigation where children directly practice self-saving actions. The physical fun games mitigation program provides children with emergency skills, knowledge of evacuation routes, how to use safety equipment, and actions to take in emergency situations. Children's knowledge of mitigation makes children agents of change in building a culture of safety and disaster mitigation in their environment.