Дигитални репозиторијум ВАСЕЉЕНА

Дигитални репозиторијум ВАСЕЉЕНА је заједнички репозиторијум свих чланица Универзитета у Источном Сарајеву.

  • ВАСЕЉЕНА је институционални репозиторијум Универзитета у Источном Сарајеву успостављен 2023. године са циљем дијељена истраживачких резултата Универзитета. Циљ репозиторијума је да дугорочно чува и омогући отворени приступ резултатима истраживања Универзитета у Источном Сарајеву широј заједници како би се допринијело академском и друштвеном напретку.
  • У репозиторијуму се похрањују публикације (научни радови, књиге, монографије и друго) са отвореним приступом.
  • За више информација као и за начине уношења публикација молимо Вас да се обратите библиотеци на Вашем факултету/академији.
  • Репозиторијум је развијен од стране Универзитетског рачунарског центра.
 

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Renal Manifestations of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome: A Systematic Review of 71 Cases
(MDPI, 2023) Dagnon da Silva, Marilia; Domingues, Sidney Marcel; Oluic, Stevan; Radovanovic, Milan; Kodela, Pratyusha; Nordin, Terri; Paulson, Margaret R.; Joksimović, Bojan; Adetimehin, Omobolanle; Singh, Devender; Madrid, Cristian; Cardozo, Milena; Baralic, Marko; Dumic, Igor
Unlike other adverse drug reactions, visceral organ involvement is a prominent feature of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome and correlates with mortality. The aim of this study was to systematically review cases published in PubMed-indexed, peer-reviewed journals in which patients had renal injury during the episode of DRESS syndrome (DS).We found 71 cases, of which 67 were adults and 56% were males. Female sex was associated with higher mortality. Chronic kidney disease (CKD) was present in 14% of patients who developed acute kidney injury (AKI) during DS. In 21% of cases, the kidneys were the only visceral organ involved, while 54% of patients had both liver and kidney involvement. Eosinophilia was absent in 24% of patients. The most common classes of medication associated with renal injury in DS were antibiotics in 34%, xanthine oxidase inhibitors in 15%, and anticonvulsants in 11%. Among antibiotics, vancomycin was the most common culprit in 68% of patients. AKI was the most common renal manifestation reported in 96% of cases, while isolated proteinuria or hematuria was present in only 4% of cases. In cases with AKI, 88% had isolated increase in creatinine and decrease in glomerular filtration (GFR), 27% had AKI concomitantly with proteinuria, 18% had oliguria, and 13% had concomitant AKI with hematuria. Anuria was the rarest manifestation, occurring in only 4% of patients with DS. Temporary renal replacement therapy was needed in 30% of cases, and all but one patient fully recovered renal function. Mortality of DS in this cohort was 13%, which is higher than previously reported. Medication class, latency period, or pre-existing CKD were not found to be associated with higher mortality. More research, particularly prospective studies, is needed to better recognize the risks associated with renal injury in patients with DS. The development of disease-specific biomarkers would also be useful so DS with renal involvement can be easier distinguished from other eosinophilic diseases that might affect the kidney.
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Periodontal Disease in Young Adults as a Risk Factor for Subclinical Atherosclerosis: A Clinical, Biochemical and Immunological Study
(MDPI, 2023) Cicmil, Smiljka; Cicmil, Ana; Pavlic, Verica; Krunić, Jelena; Sladoje Puhalo, Dragana; Bokonjić, Dejan; Čolić, Miodrag
Although a strong relationship between periodontal disease (PD) and atherosclerosis was shown in adults, little data are published in younger PD patients. Therefore, this study aimed to investigate and correlate clinical parameters of PD, pro- and immunoregulatory cytokines in gingival crevicular fluid (GCF) and serum, biochemical and hematological parameters associated with atherosclerosis risk, and carotid intima-media thickness (IMT) in our younger study participants (n = 78) (mean age 35.92 3.36 years) who were divided into two equal groups: subjects with and without PD. PD patients had higher values of IMT, hs-CRP, triglycerides, total cholesterol, and LDL; most proinflammatory and Th1/Th17-associated cytokines in GCF; and IL-8, IL-12, IL-18, and IL-17A in serum compared to subjects without PD. These cytokines in GCF positively correlated with most clinical periodontal parameters. Clinical periodontal parameters, TNF- and IL-8 in GCF and IL-17A, hs-CRP, and LDL in serum, had more significant predictive roles in developing subclinical atherosclerosis (IMT 0.75 mm) in comparison with other cytokines, fibrinogen, and other lipid status parameters. Hs-CRP correlated better with the proinflammatory cytokines than the parameters of lipid status. Except for serum IL-17A, there was no significant association of clinical and immunological PD parameters with lipid status. Overall, these results suggest that dyslipidemia and PD status seem to be independent risk factors for subclinical atherosclerosis in our younger PD population.
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MCDM MODEL FOR CRITICAL SELECTION OF BUILDING AND INSULATION MATERIALS FOR OPTIMISING ENERGY USAGE AND ENVIRONMENTAL EFFECT IN PRODUCTION FOCUS
(Vilnius Gediminas Technical University, 2023) ULUTAŞ, Alptekin; BALO, Figen; MIRKOVIĆ, Katarina; STEVIĆ, Željko; MOSTAFA, Mohamed M. H.
In the context of sustainable buildings, an ecological study of building and insulating materials is critical since it may assist affirm or shift the path of new technology development. Utilising sustainable material is a part of the sustainable improvement. For this reason, material fabrication is the primary process for the energy usage and release of intense environmental gaseous. The fabrication of the insulation and building materials, as in every fabrication process, comprises an energy consumption of crude materials in addition to the pollutants’ release. In buildings, insulation is a relevant technological resolution for cutting energy usage. This study aims to assess the primary energy consumption and the environmental effects of the fabrication of building and thermal isolation materials by using a new hybrid MCDM model. The proposed new hybrid MCDM model includes Fuzzy FUCOM, CCSD and CRADIS methods. While the subjective weights of the criteria were determined with the fuzzy FUCOM method, the objective weights of the criteria were determined with the CCSD method. Construction materials were listed with the CRADIS method. According to the fuzzy FUCOM method, the most important criterion was determined as the CR3 criterion, while the most important criterion according to the CCSD method was determined as the CR1 criterion. According to the combined weights, the most important criterion was determined as the CR3 criterion. According to the CRADIS method, the material with the best performance was determined as Cement Plaster. The methodology used in this study is a novel approach therefore it has not been used in any study before. In addition, since the CRADIS method is a newly developed MCDM method, the number of articles related to this method is low. Therefore, this research gap will be filled with this study.
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New in vitro findings about halogenated boroxine cytotoxicity and deregulation of cell death-related genes in GR-M melanoma cells
(Institute for Medical Research and Occupational Health, 2023) Elez-Burnjaković, Nikolina; Pojskić, Lejla; Haverić, Anja; Lojo-Kadrić, Naida; Hadžić Omanović, Maida; Ramić, Jasmin; Smajlović, Ajla; Maksimović, Milka; Haverić, Sanin
Anti-proliferative effects of halogenated boroxine – K2(B3O3F4OH) (HB) – have been confirmed in multiple cancer cell lines, including melanoma, but the exact mechanism of action is still unknown. This study aimed to determine its cytotoxic effects on human Caucasian melanoma (GR-M) cell growth in vitro as well as on the expression of cell death-related genes BCL-2, BECN1, DRAM1, and SQSTM1. GR-M and peripheral blood mononuclear (PBM) cells were treated with different HB concentrations and their growth inhibition and relative gene expression profiles were determined using the Alamar blue assay and real-time PCR. HB significantly inhibited cell growth of both GR-M and PBM cells but was even more effective in GR-M melanoma cells, as significant inhibition occurred at a lower HB concentration of 0.2 mg/mL. GR-M BCL-2 expression was significantly downregulated (P=0.001) at HB concentration of 0.4 mg/mL, which suggests that HB is a potent tumour growth inhibitor. At the same time, it upregulated BCL-2 expression in normal (PBM) cells, probably by activating protective mechanisms against induced cytotoxicity. In addition, all but the lowest HB concentrations significantly upregulated SQSTM1 (P=0.001) in GR-M cells. Upregulated BECN1 expression suggests early activation of autophagy at the lowest HB concentration in SQSTM1 cells and at all HB concentrations in PBM cells. Our findings clearly show HB-associated cell death and, along with previous cytotoxicity studies, reveal its promising anti-tumour potential
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The Importance of Establishing Financial Valuation of Fixed Assets in Public Companies whose Founders Are Local Self-Government Units in the Republic of Serbia
(2023) Radovic, Milan; Vitomir, Jelena; Popovic, Slobodan; Stojanovic, Aleksandar
Valuing company's fixed assets is one of the important tasks that top management needs to do in order to be able to make valid management decisions. This paper used data obtained from a representative survey of 170 public companies whose founders are local self-government units, which is about 25 % of such companies in the Republic of Serbia. Unlike the other studies, the authors analyzed fixed assets of a company before and after valuation of total fixed assets. Internal audits’ recommendations and top management’s assessments regarding the valuation of total fixed assets of a company were the reason why this valuation was done. It was concluded that there is a high correlation (p = .00) between the obtained total assessment given by internal auditors and top management regarding the valuation of fixed assets before and after the valuation of total fixed assets of the company.