Прегледај по Аутор "Beribaka, Mirjana"
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- СтавкаAssociation of Dietary Patterns with MRI Markers of Hepatic Inflammation and Fibrosis in the MAST4HEALTH Study(MDPI, 2022) Amanatidou, Athina I.; Kaliora, Andriana C.; Amerikanou, Charalampia; Stojanoski, Stefan; Milosevic, Natasa; Vezou, Chara; Beribaka, Mirjana; Banerjee, Rajarshi; Kalafati, Ioanna-Panagiota; Smyrnioudis, Ilias; Kurth, Mary Jo; Kannt, Aimo; Francino, M. Pilar; Visvikis-Siest, Sophie; Deloukas, Panos; Llorens, Carlos; Marascio, Fernando; Milic, Natasa; Medic-Stojanoska, Milica; Gastaldelli, Amalia; Trivella, Maria Giovanna; Dedoussis, George V.Whereas the etiology of non-alcoholic fatty liver disease (NAFLD) is complex, the role of nutrition as a causing and preventive factor is not fully explored. The aim of this study is to associate dietary patterns with magnetic resonance imaging (MRI) parameters in a European population (Greece, Italy, and Serbia) affected by NAFLD. For the first time, iron corrected T1 (cT1), proton density fat fraction (PDFF), and the liver inflammation fibrosis score (LIF) were examined in relation to diet. A total of 97 obese patients with NAFLD from the MAST4HEALTH study were included in the analysis. A validated semi-quantitative food frequency questionnaire (FFQ) was used to assess the quality of diet and food combinations. Other variables investigated include anthropometric measurements, total type 2 diabetes risk, physical activity level (PAL), and smoking status. Principal component analysis (PCA) was performed to identify dietary patterns. Six dietary patterns were identified, namely “High-Sugar”, “Prudent”, “Western”, “High-Fat and Salt”, “Plant-Based”, and “Low-Fat Dairy and Poultry”. The “Western” pattern was positively associated with cT1 in the unadjusted model (beta: 0.020, p-Value: 0.025) and even after adjusting for age, sex, body mass index (BMI), PAL, smoking, the center of the study, and the other five dietary patterns (beta: 0.024, p-Value: 0.020). On the contrary, compared with low-intake patients, those with medium intake of the “Low-Fat Dairy and Poultry” pattern were associated with lower values of cT1, PDFF, and LIF. However, patients with a “Low-Fat Dairy and Poultry” dietary pattern were negatively associated with MRI parameters (cT1: beta: 0.052, p-Value: 0.046, PDFF: beta: 0.448, p-Value: 0.030, LIF: beta: 0.408, p-Value: 0.025). Our findings indicate several associations between MRI parameters and dietary patterns in NAFLD patients, highlighting the importance of diet in NAFLD.
- СтавкаCOMPARISON OF METHODS FOR DETERMINING THE FALSIFICATION OF MILK(KEY, 2017) Vujadinović, Dragan; Beribaka, Mirjana; Vukić, Milan; Marjanović-Balaban, ŽeljkaFalsification of milk creates many difficulties in the dairy industry. Diluting milk with water can cause changes in the chemical composition, nutritional, hygienic and technological quality of milk. The aim of this study was to evaluate the possibility of applying the standard method for milk analysis for determining the presence of added water in sterilized milk products. Samples were prepared by diluting the milk with distilled water in the range from 5 to 50%, with a gradient of 5% and monitoring the impact of water on the relevant physical and chemical indicators of milk. Standard methods for milk analysis were performed, such as: determination of fat content, density, viscosity, acidity and sensory evaluation. Analysis of milk samples prepared with the proper dilution has shown that the average value of the freezing point of the milk samples ranged from -0.484 0C to -0.25 0C. Determination of the fat content showed that the fat content was constantly decreasing, from 3% (5% H2O) to 1.48% (50% H2O). With the increased proportion of water in milk, the density and viscosity were reduced, and pH value was slightly increased. Sensory evaluation was only partially accurate. In addition to cryoscopy, as a reliable method for determining the presence of added water in milk, some other methods have also proven to be reliable, such as: determination of fat content, density, viscosity and acidity.
- СтавкаEFFECTS OF INCUBATION CONDITION AND DIFFERENT STARTER STRAINS FOR THE PRODUCTION OF NITRITES FROM NATURAL NITRATE SOURCES(KEY, 2016) Vujadinović, Dragan; Beribaka, Mirjana; Vukić, Milan; Marjanović-Balaban, ŽeljkaNitrates and nitrites are used in production of meat products and they play an important role as preservatives, but also in the formation of characteristic red color and taste of the meat. Vegetable products represent a significant potential as a natural source of nitrate for producing organic cooked meat products. The aim of this paper was to investigate the effect of temperature changes on the degree and speed of reduction of nitrates to nitrite salts, using different starter strains of microorganisms. Staphylococcus carnosus was used as nitro-reducing starter culture for the first model, and S. carnosus in combination with Lactobacillus sakei, for the second model. Celery powder was used as a natural source of nitrate salts. Both models were incubated in the temperature range from 20 0C to 40 0C with a temperature gradient of 2 0C, for 24 and 48 hours. A method for determining nitrite is defined by the international standard ISO 2918:1999. Obtained values of nitrite concentrations were used to calculate the degree and speed of reduction of nitrates to nitrites. The degree and speed of a chemical reaction increase with increasing temperature. The final concentration of nitrite salts after 24 hours of incubation for the first model was 85 ± 2 ppm at 40 0C and for the same model after 48 hours of incubation, 100 ± 10 ppm (40 0C). The second model showed similar patterns of increase, 81 ± 9 ppm (24h, 40 0C) and 83 ± 10 ppm (24h, 40 0C). The concentration of nitrite salts, the degree and speed of reduction of nitrate salts after 48 hours of incubation was increased, compared to the concentration of nitrite salts after incubation for 24 hours, in both models. The starter culture in which it was used only S. carnosus, proved to be more efficient when it comes to the reduction of nitrates
- СтавкаLife History Traits in Two Drosophila Species Differently Affected by Microbiota Diversity under Lead Exposure(MDPI, 2021) Beribaka, Mirjana; Jelić, Mihailo; Tanasković, Marija; Lazić, Cvijeta; Stamenković-Radak, MarinaLife history traits determine the persistence and reproduction of each species. Factors that can affect life history traits are numerous and can be of different origin. We investigated the influence of population origin and heavy metal exposure on microbiota diversity and two life history traits, egg-to-adult viability and developmental time, in Drosophila melanogaster and Drosophila subobscura, grown in the laboratory on a lead (II) acetate-saturated substrate. We used 24 samples, 8 larval and 16 adult samples (two species two substrates two populations two sexes). The composition of microbiota was determined by sequencing (NGS) of the V3–V4 variable regions of the 16S rRNA gene. The population origin showed a significant influence on life history traits, though each trait in the two species was affected differentially. Reduced viability in D. melanogaster could be a cost of fast development, decrease in Lactobacillus abundance and the presence of Wolbachia. The heavy metal exposure in D. subobscura caused shifts in developmental time but maintained the egg-to-adult viability at a similar level. Microbiota diversity indicated that the Komagataeibacter could be a valuable member of D. subobscura microbiota in overcoming the environmental stress. Research on the impact of microbiota on the adaptive response to heavy metals and consequently the potential tradeoffs among different life history traits is of great importance in evolutionary research
- СтавкаNutrigenetic Interactions Might Modulate the Antioxidant and Anti- Inflammatory Status in Mastiha- Supplemented Patients With NAFLD(Frontiers, 2021) Kanoni, Stavroula; Kumar, Satish; Amerikanou, Charalampia; Kurth, Mary Jo; Stathopoulou, Maria G.; Bourgeois, Stephane; Masson, Christine; Kannt, Aimo; Cesarini, Lucia; Kontoe, Maria-Spyridoula; Milanović, Maja; Roig, Francisco J.; Beribaka, Mirjana; Campolo, Jonica; Jime´nez-Herna´ndez, Nuria; Milošević, Nataša; Llorens, Carlos; Smyrnioudis, Ilias; Francino, M. Pilar; Milić, Nataša; Kalior, Andriana C.; Trivella, Maria Giovanna; Ruddock, Mark W.; Dedoussis, George V.; Visvikis-Siest, SophieNon-alcoholic fatty liver disease (NAFLD) is the most common liver disease with no therapeutic consensus. Oxidation and inflammation are hallmarks in the progression of this complex disease, which also involves interactions between the genetic background and the environment. Mastiha is a natural nutritional supplement known to possess antioxidant and anti-inflammatory properties. This study investigated how a 6-month Mastiha supplementation (2.1 g/day) could impact the antioxidant and inflammatory status of patients with NAFLD, and whether genetic variants significantly mediate these effects. We recruited 98 patients with obesity (BMI ≥ 30 kg/m2) and NAFLD and randomly allocated them to either the Mastiha or the placebo group for 6 months. The anti-oxidative and inflammatory status was assessed at baseline and post-treatment. Genome-wide genetic data was also obtained from all participants, to investigate gene-by-Mastiha interactions. NAFLD patients with severe obesity (BMI > 35kg/m2) taking the Mastiha had significantly higher total antioxidant status (TAS) compared to the corresponding placebo group (P value=0.008). We did not observe any other significant change in the investigated biomarkers as a result of Mastiha supplementation alone. We identified several novel gene-by-Mastiha interaction associations with levels of cytokines and antioxidant biomarkers. Some of the identified genetic loci are implicated in the pathological pathways of NAFLD, including the lanosterol synthase gene (LSS) associated with glutathione peroxidase activity (Gpx) levels, the mitochondrial pyruvate carrier-1 gene (MPC1) and the sphingolipid transporter-1 gene (SPNS1) associated with hemoglobin levels, the transforming growth factor-beta-induced gene (TGFBI) and the micro-RNA 129-1 (MIR129-1) associated with IL-6 and the granzyme B gene (GZMB) associated with IL-10 levels. Within the MAST4HEALTH randomized clinical trial (NCT03135873, www.clinicaltrials.gov) Mastiha supplementation improved the TAS levels among NAFLD patients with severe obesity. We identified several novel genome-wide significant nutrigenetic interactions, influencing the antioxidant and inflammatory status in NAFLD.