Прегледај по Аутор "Kujundzic, Bojan"

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    Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk
    (Springer, 2016) Kujundzic, Bojan; Zeljic, Katarina; Supic, Gordana; Magic, Marko; Stanimirovic, Dragan; Ilic, Vesna; Jovanovic, Barbara; Magic, Zvonko
    Objectives The current study investigated the association between VDR EcoRV (rs4516035), FokI (rs2228570), ApaI (rs7975232) and TaqI (rs731236), CYP27B1 (rs4646536), CYP24A1 (rs2296241), and MTHFR (rs1801133) gene polymorphisms and risk of oral lichen planus (OLP) occurrence. Materials and methods The study group consisted of 65 oral lichen planus patients and 100 healthy blood donors in the control group. Single nucleotide polymorphisms were genotyped by real time PCR or PCR-restriction fragment length polymorphism (RFLP) method. Results Heterozygous as well as mutated genotype of vitamin D receptor (VDR) FokI (rs2228570) polymorphism was associated with increased oral lichen planus risk in comparison with wild type genotype (odds ratio (OR) = 3.877, p = 0.017, OR = 38.153, p = 0.001, respectively). A significantly decreased OLP risk was observed for heterozygous genotype of rs2296241 polymorphism in CYP24A1 gene compared with the wild type form (OR = 0.314, p = 0.012). VDR gene polymorphisms ApaI and TaqI were in linkage disequilibrium (D’ = 0.71, r 2 = 0.22). Identified haplotype AT was associated with decreased OLP risk (OR = 0.592, p = 0.047). Conclusion Our results highlight the possible important role of VDR FokI (rs2228570) and CYP24A1 rs2296241 gene polymorphisms for oral lichen planus susceptibility. Clinical relevance Identification of new molecular biomarkers could potentially contribute to determination of individuals with OLP predisposition.
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    DENTAL FOCAL INFECTIONS AND ALOPECIA AREATA
    (Serbian Medical Association Kragujevac district branch, 2015) Regoje, Dobrila; Golijanin, Ranko; Pinjic, Omer; Obrenovic, Miroslav; Kujundzic, Bojan
    Objective. The aim of this study was to examine the association of dental focal infections and alopecia areata in the adult population. Methods. The research was done in a medical institution, “Dermato-dento-medik Brcko dr Regoje”, and the Clinic for Dermatovenerology of University Clinical Center, Tuzla. The study included 63 patients which were treated surgically and medically according to the current therapeutic guidelines. All patients were divided into three groups. The first group of patients suffering from alopecia areata were treated only surgically, by removing the focus. In the second group there were patients who were treated by removing the focus and local dermatological therapy (most of them had periodontal disease). In the third group there were patients who were treated only with local dermatological therapy (most of them had gingival hyperplasia). Results. In total of 41 subjects the changes of alopecia areata had affected the hairy part, while 22 patients had changes on the chin. The difference in distribution, in relation to the expected even distribution, was statistically significant (2=5.7, df=1, p=0.017). However, the difference concerning the observed distribution of lesion in hairy parts and in other location between the three study groups was not statistically significant (2=0.2, df=1, p=0.676). Analysis of the outcomes of treatment for alopecia areata showed the highest effectiveness in the second group (n=21) because the hair growth appeared after 4 to 6 weeks after the initiation of the therapy. In the first group (n=20) the hair growth appeared within 6 to 8 weeks, and in the third group there was no hair growth during the monitoring period up to 8 weeks. Conclusion. Our study present novel data about relationships between dental focal infections and alopecia areata with outcomes after surgical and medical treatment, respectively.