Прегледај по Аутор "MILOVANOVIĆ, S."

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    EFFECT OF PROTAMINE SULFATE ON THE ISOLATED MESENTERIC ARTERIES OF NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS
    (Institute for Biological Research, Serbia, 2008) OREŠČANIN-DUŠIĆ, ZORANA; MILOVANOVIĆ, S.; SPASIĆ, M.; RADOJIČIĆ, R.; BLAGOJEVIĆ, D.
    We tested the relaxant effect of increased protamine sulfate (PS) amounts (10, 20, 50, 100 and 150 μg/ml) on the isolated mesenteric arteries of normotensive and spontaneously hypertensive (SH) rats, with or without endothelium. PS caused concentration-dependent relaxation of isolated mesenteric arteries in both types of rats. The relaxation effect of PS was lower in SH rats than in normotensive ones. Our results indicate that the vascular smooth muscles play a significant role in PS-mediated relaxation.
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    POTASSIUM CHANNELS OPENER PINACIDIL HAVE MULTIPLE EFFECTS ON KCl-ELICITED CONTRACTIONS OF ISOLATED NON-PREGNANT RAT UTERUS
    (University of Belgrade - Faculty of Veterinary Medicine, Belgrade, 2011) NOVAKOVIĆ, RADMILA; MILOVANOVIĆ, S.; ĆUPIĆ, V.; GOJKOVIĆ-BUKARICA, LJILJANA
    The effects of K+ channel opener, pinacidil on contractions provoked by contraction-stimulating KCl were investigated on isolated uterus of non-pregnant rats in oestrus. Pinacidil produced a more potent inhibition of 20 mM KCl–elicited contractions (pD2 = 6.57 M) than of 40 or 80mMKCl–elicited contractions (pD2=5.11 and 5.19 M, respectively). Glibenclamide, a selective blocker of adenosine triphosphate (ATP)-sensitive K+ (KATP) channels, antagonized the pinacidil-induced inhibition of contractions elicited by 20 mM KCl in a competitive manner. However, the pinacidil-induced inhibition of contractions provoked by 40 and 80 mM KCl glibenclamide was unable to prevent them. Pinacidil ability to completely relax the non-pregnant uterus pre-contracted with K+-rich solution suggests that K+ channelindependent mechanism(s) also plays a part in its relaxant effect.