Прегледај по Аутор "Mijovic, Biljana"

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    A Complex Relationship between Quality of Life, Anxiety, and Depression among General Population during Second Year of COVID-19 Pandemic: A Population-Based Study
    (MDPI, 2024) Radulovic, Danijela; Masic, Srdjan; Stanisavljevic, Dejana; Bokonjic, Dejan; Radevic, Svetlana; Rajovic, Nina; Milić, Nikola V.; Simic Vukomanovic, Ivana; Mijovic, Biljana; Vukovic, Maja; Dubravac Tanaskovic, Milena; Jojic, Mirka; Vladicic Masic, Jelena; Spaic, Dragan; Milic, Natasa M.
    The COVID-19 pandemic has had a significant impact on the global economy and public health, disrupting various aspects of daily life. Apart from its direct effects on physical health, it has also significantly affected the overall quality of life and mental health. This study employed a path analysis to explore the complex association among multiple factors associated with quality of life, anxiety, and depression in the general population of the Republic of Srpska during the pandemic’s second year. Method: A cross-sectional study was conducted on a nationally representative sample (n = 1382) of the general population (adults aged 20+) during the second year of the COVID-19 pandemic in the Republic of Srpska, Bosnia, and Herzegovina. Assessment tools included the DASS- Quality of Life Scale (QOLS), and Oslo Social Support Scale (OSSS-3). Sociodemographic factors and comorbidities were also assessed. Structural equation modeling was used to identify the direct and indirect links of various characteristics to quality of life, anxiety, and depression. Results: This study revealed a considerable prevalence of anxiety and depression symptoms (27.5% and 20.9%, respectively), with quality of life playing a significant mediating role. The constructed path model accounted for 33.1% of moderate to severe depression and 79.5% of anxiety. Negative coping was directly linked to anxiety and indirectly to depression via anxiety, while the absence of positive coping had both direct and indirect paths (through quality of life) on depression. Among variables that directly affected depression, anxiety had the highest effect. However, the bidirectional paths between anxiety and depression were also suggested by the model. Conclusions: Pandemic response strategies should be modified to effectively reduce the adverse effects on public mental health. Further research is necessary to assess the long-term effects of the pandemic on mental health and to analyze the contributing factors of anxiety and depression in the post-COVID period.
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    Challenges of using blooms of Microcystis spp. in animal feeds: A comprehensive review of nutritional, toxicological and microbial health evaluation
    (Elsevier, 2021) Chen, Liang; Giesy, John P.; Adamovsky, Ondrej; Svirčev, Zorica; Meriluoto, Jussi; Codd, Geoffrey A.; Mijovic, Biljana; Shi, Ting; Tuo, Xun; Li, Shang-Chun; Pan, Bao-Zhu; Chen, Jun; Xie, Ping
    Microcystis spp., are Gram-negative, oxygenic, photosynthetic prokaryotes which use solar energy to convert carbon dioxide (CO2) and minerals into organic compounds and biomass. Eutrophication, rising CO2 concentrations and global warming are increasing Microcystis blooms globally. Due to its high availability and protein content, Microcystis biomass has been suggested as a protein source for animal feeds. This would reduce dependency on soybean and other agricultural crops and could make use of “waste” biomass when Microcystis scums and blooms are harvested. Besides proteins, Microcystis contain further nutrients including lipids, carbohydrates, vitamins and minerals. However, Microcystis produce cyanobacterial toxins, including microcystins (MCs) and other bioactive metabolites, which present health hazards. In this review, challenges of using Microcystis blooms in feeds are identified. First, nutritional and toxicological (nutri-toxicogical) data, including toxicity of Microcystis to mollusks, crustaceans, fish, amphibians, mammals and birds, is reviewed. Inclusion of Microcystis in diets caused greater mortality, lesser growth, cachexia, histopathological changes and oxidative stress in liver, kidney, gill, intestine and spleen of several fish species. Estimated daily intake (EDI) of MCs in muscle of fish fed Microcystis might exceed the provisional tolerable daily intake (TDI) for humans, 0.04 μg/kg body mass (bm)/day, as established by the World Health Organization (WHO), and is thus not safe. Muscle of fish fed M. aeruginosa is of low nutritional value and exhibits poor palatability/taste. Microcystis also causes hepatotoxicity, reproductive toxicity, cardiotoxicity, neurotoxicity and immunotoxicity to mollusks, crustaceans, amphibians, mammals and birds. Microbial pathogens can also occur in blooms of Microcystis. Thus, cyanotoxins/xenobiotics/pathogens in Microcystis biomass should be removed/degraded/inactivated sufficiently to assure safety for use of the biomass as a primary/main/supplemental ingredient in animal feed. As an ameliorative measure, antidotes/detoxicants can be used to avoid/reduce the toxic effects. Before using Microcystis in feed ingredients/supplements, further screening for health protection and cost control is required.
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    EPIDEMIOLOGICAL CHARACTERISTICS OF HOSPITAL-ACQUIRED CLOSTRIDIUM DIFFICILE-ASSOCIATED DIARRHEA
    (University of Kragujevac, Faculty of Science, 2013) Bojanjic, Janja; Markovic-Denic, Ljiljana; Mijovic, Biljana
    Clostridium difficile is an anaerobic bacterium which produces spores that can survive for a long time in the environment. The disease spectrum caused by Clostridium difficile ranges from diarrhea to toxic megacolon and collectively they are all called Clostridium difficileassociated disease (CDAD). Since 2000, this pathogen has demonstrated an increased propensity to cause more frequent and virulent illness that is often refractory to treatment. Clostridium difficile-associated disease is usually diagnosed following the demonstration of toxins A and/or B in stool samples. The most important risk factors are: age over 65 years, broad-spectrum antibiotics, severe underlying illness, nasogastric intubation, gastrointestinal surgery, and longer hospital stay. The measures of prevention and control of Clostridium difficile in the health care settings include the appropriate use of isolation precautions, hand hygiene, protective clothing, environmental cleaning and cleaning of medical equipment, good antibiotic stewardship, and specific measures during outbreaks