Прегледај по Аутор "Mladenović, Irena"
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- СтавкаA cephalometric analysis of the cranial base and frontal part of the face in patients with mandibular prognathism(Ministry of Defance, Serbia, 2014) Čutović, Tatjana; Jović, Nebojša; Stojanović, Ljiljana; Radojičić, Julija; Mladenović, Irena; Matijević, Stevo; Kozomara, RužicaBacground/Aim. The literature suggests different views on the correlation between the cranial base morphology and size and saggital intermaxillary relationships. The aim of this study was to investigate the cranial base morphology, including the frontal facial part in patients with mandibular prognathism, to clarify a certain ambiguities, in opposing viewspoints in the literature. Methods. Cephalometric radiographies of 60 patients were analyzed at the Dental Clinic of the Military Medical Academy, Belgrade, Serbia. All the patients were male, aged 18–35 years, with no previous orthodontic treatment. On the basis of dental and sceletal relations of jaws and teeth, the patients were divided into two groups: the group P (patients with mandibular prognathism) and the group E (the control group or eugnathic patients). A total of 15 cephalometric parametres related to the cranial base, frontal part of the face and sagittal intermaxillary relationships were measured and analyzed. Results. The results show that cranial base dimensions and the angle do not play a significant role in the development of mandibular prognathism. Interrelationship analysis indicated a statistically significant negative correlation between the cranial base angle (NSAr) and the angles of maxillary (SNA) and mandibular (SNB) prognathism, as well as a positive correlation between the angle of inclination of the ramus to the cranial base (GoArNS) and the angle of sagittal intermaxillary relationships (ANB). Sella turcica dimensions, its width and depth, as well as the nasal bone length were significantly increased in the patients with mandibular prognathism, while the other analyzed frontal part dimensions of the face were not changed by the malocclusion in comparison with the eugnathic patients. Conclusion. This study shows that the impact of the cranial base and the frontal part of the face on the development of profile in patients with mandibular prognathism is much smaller, but certainly more complex, so that morphogenetic tests of the maxillomandibular complex should be included in further assessment of this impact.
- СтавкаCephalometric analysis of the middle part of the face in patients with mandibular prognathism(Ministry of Defance, Serbia, 2014) Čutović, Tatjana; Jović, Nebojša; Kozomara, Ružica; Radojičić, Julija; Janošević, Mirjana; Mladenović, Irena; Matijević, StevoBackground/Aim. The middle part of the face, that is the maxilla, has always been mentioned as a possible etiologic factor of skeletal Class III. However, the importance of the relationship of maxillary retroposition towards the cranial base is still unclear, although it has been examined many times. The aim of this study was to conduct cephalometric analysis of the morphology of maxilla, including the whole middle part of the face in patients with divergent and convergent facial types of mandibular prognathism, as well as to determine differences betweeen them. Methods. Lateral cephalometric teleradiograph images of 90 patients were analyzed at the Dental Clinic of the Military Medical Academy, Belgrade, Serbia. All the patients were male, aged 18–35 years, not previously treated orthodontically. On the basis of dentalskeletal relations of jaws and teeth, the patients were divided into three groups: the group P1 (patients with divergent facial type of mandibular prognathism), P2 (patients with convergent facial type of mandibular pragmathism) and the group E (control group or eugnathic patients). A total of 9 cephalometric parameters related to the middle face were measured and analyzed: the length of the hard palate – SnaSnp, the length of the maxillary corpus – AptmPP, the length of the soft palate, the angle between the hard and soft palate – SnaSnpUt, the angle of inclination of the maxillary alveolar process, the angle of inclination of the upper front teeth, the effective maxillary length – CoA, the posterior maxillary alveolar hyperplasia – U6PP and the angle of maxillary prognathism. Results. The obtained results showed that the CoA, AptmPP and SnaSnp were significally shorter in patients with divergent facial type of mandibular prognathism compared to patients with convergent facial type of the mandibular prognathism and also in both experimental groups of patients compared to the control group. SnaSnp was significantly shorter in patients with divergent facial type of mandibular prognathism compared to the control group, whereas SnaSnp was significantly smaller in patients with convergent facial type of mandibular prognathism compared to the control group. Additionally, there was a pronounced incisor dentoalveolar compensation of skeletal discrepancy in both groups of patients with mandibular prognathism manifested in the form of a significant upper front teeth protrusion, but without significant differences among the groups, while the maxillary retrognathism was present in most patients of both experimental groups. A pronounced UGPP was found only in the patients with divergent type of mandibular prognathism. Conclusion. The maxilla is certainly one of the key factors which contributes to making the diagnosis, but primarily to making a plan for mandibular prognathism treatment. Accurate assessment of the manifestation of abnormality, localization of skeletal problems and understanding of the biological potential are key factors of the stability of the results of surgical-orthodontic treatment of this abnormality.
- СтавкаDental pulp pain in young and postmenopausal women: a pilot study(Serbian Medical Society - Dental Section, Belgrade, Serbia, 2016) Krunić, Jelena; Mladenović, Irena; Stojanović, NikolaIntroduction This pilot study was aimed to compare pulpal pain provoked by electrical and thermal (cold) stimuli in healthy young women during various phases of menstrual cycle and postmenopausal women. Material and methods The study included 20 regularly menstruating healthy women and 20 postmenopausal women. Electrical (electrical pulp tester) and cold (refrigerant spray) stimuli were performed on mandibular central incisors, twice in regularly menstruating (menstrual and luteal phases) and once in postmenopausal women. Results were expressed as pain threshold values for electrical pulp stimulation (0-80 units) and pain intensity scores (visual numeric scale, from 0 to 10) for cold stimulation. Results In young women, higher pain electrical threshold (p=0.484) and pain sensitivity score (p=0.015) were observed in luteal in comparison to menstrual phase. In postmenopausal women, electrical pain threshold was significantly higher while pain intensity score was significantly lower than in young women, regardless of the menstrual phase and painful stimuli. Conclusion Lower responsiveness to dental pulp pain was obtained in young women in luteal phase and postmenopausal women
- СтавкаInfluence of different forms of calcium hydroxide and chlorhexidine intracanal medicaments on the outcome of endodontic treatment of teeth with chronic apical periodontitis(Serbian Medical Association, Belgrade, 2018) Stojanović, Nikola; Krunić, Jelena; Mladenović, Irena; Stojanović, Zorica; Apostolska, Sonja; Živković, SlavoljubIntroduction/Objective The aim of this study was to determine clinical and radiographic periapical healing of teeth with apical periodontitis treated with different formulations of calcium hydroxide (CH) – paste (CH-paste) and gutta-percha points (CH-GP) – as well as those of chlorhexidine (CHX) – gel (CHXgel) and gutta-percha points (CHX-GP) –12 months after therapy. Methods Eighty patients with chronic apical periodontitis were randomly allocated to four treatment groups according to the intracanal medicament used: CH-paste, CH-GP, CHX-gel, and CHX-GP group. Seventy-eight patients were analyzed clinically and radiographically 12 months postoperatively. The periapical index (PAI) was used for the radiographic evaluation of treatment. Results Overall outcome was classified according to radiographic evaluation only, since clinical success was observed in all the patients. In all the groups, significant reduction in PAI scores was observed (p < 0.001). The proportions of healed teeth (PAI ≤ 2) were 73.7%, 60%, 68.4%, and 65% in CH-paste, CH-GP, CHX-gel and CHX-GP group, respectively, with no significant differences between the groups. Conclusion The results suggest that there are no differences between investigated CH- and CHX-delivery systems regarding treatment outcome of teeth with apical periodontitis.
- СтавкаMultidisciplinary treatment of complex skeletal class III malocclusion(Ministry of Defance, Serbia, 2018) Čutović, Tatjana; Radojičić, Julija; Stošić, Srboljub; Mladenović, Irena; Kozomara, RužicaIntroduction. Skeletal malocclusions, especially those with a prominent vertical component, always present a challenge for the interdisciplinary approach to their treatment planning. The aim of this report is to present a patient with complex skeletal deformity in all three directions (vertical, sagittal and transverse). Case report. A twenty-four year old female patient with a skeletal Class III malocclusion, open bite and laterognathia, was firstly treated by orthodontic fixed appliances, whereas the dental decompensation of dentoalveolar structures was carried out and adjusted to their bone structures, thus enabling an adequate and sufficient reposition of the jaw. A surgical correction included bi-maxillary osteotomy due to pronounced vertical cephalometric parameters, necessitating a posterior maxillary intrusion and mandibular repositioning. In that manner, the relapse was prevented and a long-term stable result obtained. In the retention period, the patient wore removable bi-maxillary retention devices. Conclusion. The combined orthodontic-surgical treatment provided the Class I occlusion with aesthetic and functionally satisfactory results which were envisioned by the treatment plan.
- СтавкаVesicular Messages from Dental Biofilms for Neutrophils(MDPI, 2024) Vitkov, Ljubomir; Krunić, Jelena; Dudek, Johanna; Reddy Bobbili, Madhusudhan; Grillari, Johannes; Hausegger, Bernhard; Mladenović, Irena; Stojanović, Nikola; Dietrich Krautgartner, Wolf; Oberthaler, Hannah; Schauer, Christine; Herrmann, Martin; Singh, Jeeshan; Minnich, Bernd; Hannig, MatthiasThe encounter between dental biofilm and neutrophils in periodontitis remains elusive, although it apparently plays a crucial role in the periodontal pathology and constitutes a key topic of periodontology. Dental biofilm and neutrophils were isolated from orally healthy persons and patients with periodontitis. We investigated biofilm and its particle-shedding phenomenon with electron microscopy and nanoparticle tracking analysis (NTA); biofilm shedding–neutrophil interactions were examined ex vivo with epi-fluorescence microscopy. For this purpose, we used acellular dental biofilm shedding, purified lipopolysaccharide (LPS), and phorbol 12-myristate 13-acetate (PMA) as activators, and the interleukin 8 receptor beta (CXCR2) inhibitor and the anti-interleukin 8 receptor alpha (CXCR1) antibody as modulators. The shedding of acellular dental biofilms overwhelmingly consists of bacterial extracellular vesicles (BEVs). The latter induced the moderate formation of neutrophil extracellular traps (NETs) in orally healthy subjects and a strong formation in patients with periodontitis. A CXCR2 inhibitor and an anti-CXCR1 antibody had a minor effect on NET formation. Neutrophils from patients with periodontitis exhibited NET hyper-responsiveness. BEVs were stronger inducers of NET formation than purified LPS and PMA. A plateau of neutrophil responsiveness is reached above the age of 40 years, indicating the abrupt switch of maladaptive trained immunity (TI) into the activated modus. Our results suggest that dental biofilms consist of and disseminate immense amounts of outer membrane vesicles (OMVs), which initiate NET formation via a non-canonical cytosolic LPS/caspase-4/11/Gasdermin D pathway. This modus of NET formation is independent of neutrophil elastase (NE), myeloperoxidase (MPO), peptidylarginine deiminase 4 (PAD4), and toll-like receptors (TLR). In periodontitis, the hyper-responsiveness of neutrophils to BEVs and the increased NET formation appear to be a consequence of TI.