Прегледај по Аутор "Obrenović, Miroslav"

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    FREQUENCY OF SPECIFIC PATHOLOGICAL PROCESSES – FOCAL DENTAL INFECTIONS IN PATIENTS WITH ALOPECIA AREATA
    (Serbian Medical Association Kragujevac district branch, 2015) Regoje, Dobrila; Golijanin, Ranko; Pinjić, Omer; Obrenović, Miroslav; Kujundžić, Bojan; Miletić, Nataša
    The aim of this study was to determine the frequency of specific pathological processes on teeth in patients with alopecia areata. The research was done in medical-esthetic center "Dermato-dentomedik" in Brcko and the Clinic for Dermatovenerology of University Clinical Center, Tuzla. The study included 75 patients which were divided into three groups. The first group consisted of patients suffering from alopecia areata treated only surgically. The second group consisted of patients suffering from alopecia areata treated with surgical and local dermatological therapy. The third group included patients suffering from alopecia areata treated only with dermatological therapy. In the first group of patients (n = 20) who were treated only by removing the focus, the most common pathological processes were chronic apical lesions and cysts (30%). In the second group of patients (n = 27) who were treated by removing the focus and local dermatological therapy the most frequent was periodontal disease with 29.6%. In the third group of patients (n = 26) who were treated with a local dermatological therapy, the most common pathological processes were chronic apical lesions (38.5%), cysts (26.9%) and periodontal (19.2%). Our study presents the frequency of pathological odontogenic focus in alopecia areata, with the importance of a common multidisciplinary approach to treatment which can be accomplished the greatest success in the treatment of alopecia areata.
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    Morphometric analysis of collagen and inflammatory cells in periodontal disease
    (University of Defence - Faculty of Medicine of the Military Medical Academy, 2015) Golijanin, Ranko; Kujundžić, Bojan; Milosavljević, Zoran; Milovanović, Dragan R.; Andjelković, Zlatibor; Obrenović, Miroslav; Nikolić, Radivoje
    Background/Aim. Periodontal disease affects gingival tissue and supporting apparatus of the teeth leading to its decay. The aim of this study was to highlight and precisely determine his-tological changes in the gum tissue. Methods. Gingival biopsy samples from 53 healthy and parodontopathy-affected patients were used. Clinical staging of the disease was performed. Tissue specimens were fixed and routinely processed. Sections, 5 μm thin, were stained with hematoxylin and eosin, histochemical Van-Gieson for the collagen content, Spicer method for mast-cells and immunochemical method with anti-CD68 and anti-CD38 for the labelling of the macrophages and plasma-cells. Morphometric analysis was performed by a M42 test system. Results. While the disease advanced, collagen and fibroblast volume density decreased almost twice in the severe cases compared to the control ones, but a significant variation was observed within the investigated groups. The mast-cell number increased nearly two times, while the macrophage content was up to three times higher in severe parodontopathy than in healthy gingival tissue. However, the relative proportion of the-se cells stayed around 6% in all cases. Plasma-cells had the most prominent increase in the number (over 8 times) com-pared to the control, but again, a variation within investigated groups was very high. Conclusion. Gingival tissue destruction caused by inflammatory process leads to significant changes in collagen density and population of resident connective tissue cells. Although inflammatory cells dominated with the disease advancing, a high variation within the same investigated groups suggests fluctuation of the pathological process.