Прегледај по Аутор "Pavlović, Bojan"

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    Effects of aerobic physical activity to cardio-respiratory fitness of the elderly population: systematic overview
    (IP Iermakov S.S., 2020) Aksović, Nikola; Bjelica, Bojan; Joksimović, Marko; Skrypchenko, Iryna; Filipović, Siniša; Milanović, Filip; Pavlović, Bojan; Ćorluka, Bojan; Pržulj, Radomir
    Purpose: Aerobic training is effective manner of exercising aimed at improving cardio-respiratory fitness of young people. However, its effects to the elderly population (over the age of 60), depending on characteristics of the participant (gender, health status, lifestyle, etc.), is still unclear. Aim of this research is systematic overview of the available literature dealing with the topic of effects of aerobic training to cardiorespiratory fitness of the elderly population over the age of 60, depending of gender (male/female), BMI (overweight/normal weight), lifestyle (active/sedentary), health status (diabetes/hypertension/ metabolic syndrome). Material: Total number of papers with published research results which met the criteria was 32. Walking is effective manner of exercising which influences improvement of maximum oxygen consumption (mean value: ±SD:12.91±7.40%). Introduction of activities with greater impact (bicycle and jogging) provides more effect to the cardio-respiratory fitness (mean value: ±SD:14.28±7.48%). Results: Aerobic training intensity level (moderate vs. high) makes no significant difference to the adaptive response of the cardio respiratory fitness in elderly population. Training in duration of 6 weeks may significantly influence increase in maximum oxygen consumption, but longer training duration, however, has better effect. Endurance training has similar effects to improvement of cardio-respiratory fitness in both men and women. On the other hand, it seems that active people have lower adaptive response in comparison to sedentary people (8.3% vs. 18.84%). Effect is similar between overweight and normal weight participants (18.48% vs. 8.6%). Positive influence of aerobic training was also observed in participants with hypertension, metabolic system and diabetes type 2. Conclusions: Results clearly suggest benefits of aerobic training on cardio-respiratory fitness of elderly population. The effect may, however, vary depending of duration, type of activity, as well as characteristics of the sample.
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    Fecal microbiota composition associates with the capacity of human peripheral blood monocytes to differentiate into immunogenic dendritic cells in vitro
    (2021) Radojević, Dušan; Tomić, Sergej; Mihajlović, Dušan; Tolinački, Maja; Pavlović, Bojan; Vučević, Dragana; Bojić, Svetlana; Golić, Nataša; Čolić, Miodrag; Đokić, Jelena
    Although promising for active immunization in cancer patients, dendritic cells (DCs) vaccines generated in vitro display high inter-individual variability in their immunogenicity, which mostly limits their therapeutic efficacy. Gut microbiota composition is a key emerging factor affecting individuals’ immune responses, but it is unknown how it affects the variability of donors’ precursor cells to differentiate into immunogenic DCs in vitro. By analyzing gut microbiota composition in 14 healthy donors, along with the phenotype and cytokines production by monocyte-derived DCs, we found significant correlations between immunogenic properties of DC and microbiota composition. Namely, donors who had higher α-diversity of gut microbiota and higher abundance of short-chain fatty acid (SCFAs) and SCFA-producing bacteria in feces, displayed lower expression of CD1a on immature (im)DC and higher expression of ILT-3, costimulatory molecules (CD86, CD40) proinflammatory cytokines (TNF-α, IL-6, IL-8) and IL-12p70/IL-10 ratio, all of which correlated with their lower maturation potential and immunogenicity upon stimulation with LPS/IFNγ, a well-known Th1 polarizing cocktail. In contrast, imDCs generated from donors with lower α-diversity and higher abundance of Bifidobacterium and Collinsella in feces displayed higher CD1a expression and higher potential to up-regulate CD86 and CD40, increase TNF-α, IL-6, IL-8 production, and IL-12p70/IL-10 ratio upon stimulation. These results emphasize the important role of gut microbiota on the capacity of donor precursor cells to differentiate into immunogenic DCs suitable for cancer therapy, which could be harnessed for improving the actual and future DC-based cancer therapies.
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    Nanotechnology in medicine revolutionizing drug delivery for cancer and viral infection treatments
    (Elsevier, 2024) Karahmet Sher, Emina; Alebić, Mirna; Marković Boras, Marijana; Boškailo, Emina; Karahmet Farhat, Esma; Karahmet, Alma; Pavlović, Bojan; Sher, Farooq; Lekić, Lana
    Advancements in nanotechnology were vastly applied in medicine and pharmacy, especially in the field of nanodelivery systems. It took a long time for these systems to ensure precise delivery of very delicate molecules, such as RNA, to cells at concentrations that yield remarkable efficiency, with success rates reaching 95.0% and 94.5%. These days, there are several advantages of using nanotechnological solutions in the prevention and treatment of cancer and viral infections. Its interventions improve treatment outcomes both due to increased effectiveness of the drug at target location and by reducing adverse reactions, thereby increasing patient adherence to the therapy. Based on the current knowledge an updated review was made, and perspective, opportunities and challenges in nanomedicine were discussed. The methods employed include comprehensive examination of existing literature and studies on nanoparticles and nano-delivery systems including both in vitro tests performed on cell cultures and in vivo assessments carried out on appropriate animal models, with a specific emphasis on their applications in oncology and virology. This brings together various aspects including both structure and formation as well as its association with characteristic behaviour in organisms, providing a novel perspective. Furthermore, the practical application of these systems in medicine and pharmacy with a focus on viral diseases and malignancies was explored. This review can serve as a valuable guide for fellow researchers, helping them navigate the abundance of findings in this field. The results indicate that applications of nanotechnological solutions for the delivery of medicinal products improving therapeutic outcomes will continue to expand.