Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos

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dc.citation.epage1044
dc.citation.spage1033
dc.citation.volume68
dc.contributor.authorAntonijević, Biljana
dc.contributor.authorStojiljković, Miloš P.
dc.contributor.authorBokonjić, Dubravko
dc.contributor.authorVučinić, Slavica
dc.date.accessioned2023-09-14T09:38:23Z
dc.date.available2023-09-14T09:38:23Z
dc.date.issued2011
dc.description.abstractIn acute organophosphate poisoning the issue of special concern is the appearance of muscle fasciculations and convulsions that cannot be adequately antagonised by the use of atropine and oxime therapy. The aim of this study was to examine atidotal effect of obidoxime or HI-6 combinations with memantine in mice poisoned with soman, dichlorvos or heptenophos. Methods. Male Albino mice were pretreated intravenously (iv) with increasing doses of oximes and/or memantine (10 mg/kg) at various times before poisoning with 1.3 LD-50 of soman, dichlorvos or heptenophos, in order to determine the median effective dose and the efficacy half-time. In a separate experiment, cerebral extravasation of Evans blue dye (40 mg/kg iv) was examined after application of memantine (10 mg/kg iv), midazolam (2.5 mg/kg intraperitonealy – ip) and ketamine (20 mg/kg ip) 5 minutes before soman (1 LD-50 subcutaneously – sc). Results. Coadministration of memantine induced a significant decrease in median effective dose in null time of both HI-6 (7.96 vs 1.79 moL/kg in soman poisoning) and obidoxime (16.80 vs 2.75 moL/kg in dichlorvos poisoning; 21.56 vs 6.63 moL/kg in heptenophos poisoning). Memantine and midazolam succeded to counteract the soman-induced proconvulsive activity. Conclusion. Memantine potentiated the antidotal effect of HI-6 against a lethal dose of soman, as well as the ability of obidoxime to antagonize the toxic effects of dichlorvos and heptenophos probably partly due to its anticonvulsive properties
dc.identifier.doi10.2298/VSP1112033A
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/758
dc.language.isoen
dc.publisherMinistry of Defance, Serbia
dc.sourceVojnosanitetski pregled
dc.subjectorganophosphorus compounds; poisoning; antidotes; oximes; memantine; obidoxime chloride; anticonvulsants
dc.titleAntidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos
dc.typeArticle
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