Periodontitis-Derived Dark-NETs in Severe Covid-19

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dc.citation.spage872695
dc.citation.volume13
dc.contributor.authorVitkov, Ljubomir
dc.contributor.authorKnopf, Jasmin
dc.contributor.authorKrunić, Jelena
dc.contributor.authorSchauer, Christine
dc.contributor.authorSchoen, Janina
dc.contributor.authorMinnich, Bernd
dc.contributor.authorHannig, Matthias
dc.contributor.authorHerrmann, Martin
dc.date.accessioned2023-05-16T07:33:28Z
dc.date.available2023-05-16T07:33:28Z
dc.date.issued2022
dc.description.abstractThe frequent severe COVID-19 course in patients with periodontitis suggests a link of the aetiopathogenesis of both diseases. The formation of intravascular neutrophil extracellular traps (NETs) is crucial to the pathogenesis of severe COVID-19. Periodontitis is characterised by an increased level of circulating NETs, a propensity for increased NET formation, delayed NET clearance and low-grade endotoxemia (LGE). The latter has an enormous impact on innate immunity and susceptibility to infection with SARS-CoV-2. LPS binds the SARS-CoV-2 spike protein and this complex, which is more active than unbound LPS, precipitates massive NET formation. Thus, circulating NET formation is the common denominator in both COVID-19 and periodontitis and other diseases with lowgrade endotoxemia like diabetes, obesity and cardiovascular diseases (CVD) also increase the risk to develop severe COVID-19. Here we discuss the role of propensity for increased NET formation, DNase I deficiency and low-grade endotoxaemia in periodontitis as aggravating factors for the severe course of COVID-19 and possible strategies for the diminution of increased levels of circulating periodontitis-derived NETs in COVID-19 with periodontitis comorbidity.
dc.identifier.doi10.3389/fimmu.2022.872695
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/146
dc.language.isoen
dc.publisherFrontiers
dc.sourceFrontiers in Immunology
dc.subjectneutrophil hyper-responsiveness, dysregulated immunity, trained immunity, NET hyper-responsiveness, NET-induced damage, inhibition of NET formation
dc.titlePeriodontitis-Derived Dark-NETs in Severe Covid-19
dc.typeArticle
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