Increased systemic sST2 in patients with end stage renal disease contributes to milder liver damage during HCV infection

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dc.citation.epage526
dc.citation.spage519
dc.citation.volume14
dc.contributor.authorLukic, Ruzica
dc.contributor.authorCupic, Majа
dc.contributor.authorGajovic, Nevena
dc.contributor.authorJurisevic, Milena
dc.contributor.authorMijailovic, Zeljko
dc.contributor.authorDavidovic, Bojana
dc.contributor.authorKujundžic, Bojan
dc.contributor.authorJoksimovic, Bojan
dc.contributor.authorArsenijevic, Nebojša
dc.contributor.authorJovanovic, Ivan
dc.date.accessioned2023-07-04T10:58:38Z
dc.date.available2023-07-04T10:58:38Z
dc.date.issued2020
dc.description.abstractIntroduction: Hepatitis C Virus (HCV) is the leading cause of chronic liver disease and is a serious global health problem. Hepatitis C infection is highly prevalent in patients with end stage renal disease (ESRD), due to frequent exposure to blood and blood products, nosocomial transmission of HCV, and prolong hemodialysis duration. The aim of the study was to evaluate the influence of IL-33/ST2 signaling pathway on severity of the liver disease in ESRD HCV+ patients. Methodology: Blood samples from patients with end stage renal disease (ESRD) and hepatitis C infection (HCV), 20 patients with HCV infection, 20 patients with ESRD and 20 healthy control donor patients were taken for the examination of biochemical parameters, for the determination of the serum cytokine concentration, and for the molecular diagnostics of HCV. Results: Systemic sST2 positively correlated with serum level of urea and creatinine, respectively. Serum sST2 was significantly increased in ESRD HCV+ patients in comparison to HCV+ group. sST2/IL-1, sST2/IL-4 and sST2/IL-23 ratios were significantly increased in serum of ESRD HCV+ patients in comparison to HCV+ patients. Significantly higher systemic level of sST2 and sST2/IL-1 and sST2/IL-4 ratios were measured in ESRD patients compared to non-ESRD patients. Conclusion: These results suggested that elevated level sST2, as the consequence of renal failure, causes less destruction of liver in HCV infection
dc.identifier.doi10.3855/jidc.11741
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/338
dc.language.isoen
dc.sourceThe Journal of Infection in Developing Countries
dc.subjectHCV; end-stage renal disease; sST2.
dc.titleIncreased systemic sST2 in patients with end stage renal disease contributes to milder liver damage during HCV infection
dc.typeArticle
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