The Impact of Cytokines on Health-Related Quality of Life in Adolescents with Allergic Rhinitis

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dc.citation.spage428
dc.citation.volume12
dc.contributor.authorKrsmanović, Ljiljana
dc.contributor.authorArsović, Nenad
dc.contributor.authorBokonjić, Dejan
dc.contributor.authorNešić, Vladimir
dc.contributor.authorDudvarski, Zoran
dc.contributor.authorPavlović, Dragana
dc.contributor.authorDubravac Tanasković, Milena
dc.contributor.authorRistić, Siniša
dc.contributor.authorElez-Burnjaković, Nikolina
dc.contributor.authorBalaban, Radmila
dc.contributor.authorĆurčić, Branislava
dc.contributor.authorIvanović, Radenko
dc.contributor.authorVuković, Nikolina
dc.contributor.authorVuković, Maja
dc.contributor.authorMilić, Marija
dc.contributor.authorJoksimović, Bojan
dc.date.accessioned2024-11-06T10:42:48Z
dc.date.available2024-11-06T10:42:48Z
dc.date.issued2024
dc.description.abstractBackground: Frequent episodes of nasal symptoms are the usual clinical manifestations (CM) of allergic rhinitis (AR) and have a significant negative impact on health-related quality of life (HRQoL) in adolescents. The purpose of this cross-sectional study was to test the hypothesis that cytokines in nasal mucus may be associated with HRQoL in adolescents with AR. Methods: European Quality of Life 5 Dimensions 3 Level Version (EQ-5D-3L), “The Adolescent Rhinoconjunctivitis Quality of Life Questionnaire” (AdolRQLQ) and the Total 4 Symptom Score (T4SS) scoring system were administered to 113 adolescents with AR, nonallergic rhinitis (NAR) and to healthy control subjects. Nasal secretions were sampled and tested for 13 cytokines using a multiplex flow cytometric bead assay. Results: The AR group had significantly lower EQ-5D-3L (0.661 ± 0.267 vs. 0.943 ± 0.088; p < 0.001) and higher AdolRQLQ total scores (2.76 ± 1.01 vs. 1.02 ± 0.10; p < 0.001) compared to the control group. The AR group had higher concentrations of IL-1β (p = 0.002), IL-6 (p = 0.031), IL-8 (p < 0.001), IL17-A (p = 0.013) and IL-18 (p = 0.014) compared to the control group, and IL-1β, IL-6, IL17-A and IL-18 were significantly (p < 0.050) increased with disease progression. Cytokines IL-1β, IL-6, as well as severe CM, were identified as significant predictors of lower HRQoL in adolescents with AR. Conclusions: This study identified IL-1β, IL-6, as well as severe CM, as predictors of lower HRQoL in adolescents with AR. However, these results should only serve as a starting point for additional confirmation research.
dc.identifier.doi10.3390/biomedicines12020428
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/1238
dc.language.isoen
dc.publisherMDPI
dc.sourceBiomedicines
dc.subjectallergic rhinitis; cytokines; health-related quality of life; adolescents
dc.titleThe Impact of Cytokines on Health-Related Quality of Life in Adolescents with Allergic Rhinitis
dc.typeArticle
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