The comparison of SARS-CoV-2 antibody levels in medical personnel induced by different types of vaccines compared to the natural infection

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dc.citation.epage42
dc.citation.spage35
dc.citation.volume48
dc.contributor.authorBOŽIĆ, LJILJANA
dc.contributor.authorKNEŽEVIĆ, DARIJA
dc.contributor.authorTRAVAR, MAJA
dc.contributor.authorMILJUŠ, NATAŠA
dc.contributor.authorPETKOVIĆ, MIROSLAV
dc.contributor.authorAĆIMOVIĆ, JELA
dc.contributor.authorDJAKOVIĆ DEVIĆ, JELENA
dc.contributor.authorSTOJILJKOVIĆ, MILOŠ P.
dc.contributor.authorBOKONJIĆ, DEJAN
dc.contributor.authorŠKRBIĆ, RANKO
dc.date.accessioned2024-12-11T12:42:18Z
dc.date.available2024-12-11T12:42:18Z
dc.date.issued2023
dc.description.abstractIntroduction: During the last two and a half years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread around the world. Most of the SARS-CoV-2 vaccines are designed to produce anti-SARS-CoV-2 immunoglobulin G (IgG) against the viral S-glycoprotein. The aim of this study was to measure the anti-S antibody titres among the medical personnel who had been fully vaccinated with different types of vaccines, and to compare them with those who were COVID-19 convalescents. Material and methods: In this study serum was collected from 261 healthcare workers, of whom 227 were vaccinated, while 34 were recovered participants who were not immunised. Serum samples were collected 21 days after the first dose and 60 and 180 days after the second dose of the vaccines and tested with a commercial ELISA kit. Results: The highest antibody level (12 AU/ml) was measured in the Pfizer-BioNTech group, followed by Sinopharm (9.3 AU/ml), Sputnik V (5.9 AU/ml), Sinovac (4.6 AU/ml) and Oxford/Astra- Zeneca vaccine (2.5 AU/ml) 60 days after the second dose of the vaccines (90 days after the first dose). The seropositivity rate for mRNA vaccine was 88.5%, for vector vaccines 86.2% and for inactivated vaccines 71.4%. When comparing these antibody levels with COVID-19 convalescents, higher antibody titres were found in vaccinated participants (5.76 AU/ml vs 7.06 AU/ml), but the difference was not significant (p = 0.08). Conclusions: Individuals vaccinated with mRNA and vector vaccines had a higher seroconversion rate compared to the group vaccinated with inactivated vaccines, or convalescents.
dc.identifier.doi10.5114/ceji.2023.125239
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/1393
dc.language.isoen
dc.sourceClinical immunology
dc.subjectCOVID-19, IgG antibody, immunity, SARS-CoV-2, vaccines
dc.titleThe comparison of SARS-CoV-2 antibody levels in medical personnel induced by different types of vaccines compared to the natural infection
dc.typeArticle
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