Primary breast angiosarcoma in postmenopausal women with a picture like Kasabach-Merritt syndrome – A case report

Једноставна страница ставке
dc.citation.epage478
dc.citation.spage475
dc.citation.volume78
dc.contributor.authorĆuk, Mirjana
dc.contributor.authorGajanin, Radoslav
dc.contributor.authorMarić, Radmil
dc.contributor.authorMarić, Veljko
dc.contributor.authorTodorović, Svjetlana
dc.contributor.authorVasić Milanović, Milena
dc.date.accessioned2023-06-07T07:23:18Z
dc.date.available2023-06-07T07:23:18Z
dc.date.issued2021
dc.description.abstractIntroduction. Primary angiosarcoma of the breast (PAB) is a very rare tumor and accounts for 0.04% of all breast malignant tumors and most commonly occurs in young women. Kasabach-Merritt syndrome (KMS) is described as consumption coagulopathy with thrombocytopenia, and without adequate therapy almost certainly leads to a very fast lethal outcome. The literature contains only a few cases of PAB associated with thrombocytopenia or with KMS and there are no clear defined protocols for the treatment of these patients, which requires the presentation of as many cases as possible. Case report. We presented a rare case of 60-year-old postmenopausal woman with metastatic PAB grade III associated with a picture like KMS (thrombocytopenia and anemia without the coagulation factor disorder with massive bleeding in the tumor). Mastectomy was performed without the ex-tirpation of the axillary region. After the surgery, im-provement with anemia and thrombocytopenia was no-ticed. One month after the surgery, supportive and symptomatic therapy was administered, as well as bish-osphonate therapy, but with temporary improvement. Deplasmated erythrocytes and methylprednisolone were added during the another hospital stay, but prominent symptoms of general weakness along with the progres-sion od thrombocytopenia were noted. Fibrinogen and coagulation factors were within reference values all the time. The patient died four months after the surgery. Conclusion. PAB in postmenopausal women is a very rare tumor, and may be associated with anemia and thrombocytopenia without other laboratory parameters for KMS. Anemia and thrombocytopenia are refractory to standard treatment protocols, and also significantly reduces the quality of life of these patients
dc.identifier.doi10.2298/VSP180914066C
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/292
dc.language.isoen
dc.publisherMinistry of Defance, Serbia
dc.sourceVOJNOSANITETSKI PREGLED
dc.subjectangiosarcoma of the breast; breast neoplasms; diagnosis; histological techniques; immunohistochemistry; kasabach-merritt syndrome; postmenopause; thrombocytopenia; treatment outcome
dc.titlePrimary breast angiosarcoma in postmenopausal women with a picture like Kasabach-Merritt syndrome – A case report
dc.typeArticle
Датотеке
Оригинални завежљај
Сада се приказује 1 - 1 од 1
Сличица
Име:
Primary breast angiosarcoma in postmenopausal women with a picture like Kasabach-Merritt syndrome – A case report.pdf
Величина:
605.55 KB
Формат:
Adobe Portable Document Format
Опис:
Преузимање
Свежањ лиценце
Сада се приказује 1 - 1 од 1
Сличица
Име:
license.txt
Величина:
1.71 KB
Формат:
Item-specific license agreed to upon submission
Опис:
Преузимање
Колекције
Медицински факултет [Научни радови] / Faculty of Medicine [Scientific papers]