Fullerenol C60(OH)24 nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction

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dc.citation.volume15
dc.contributor.authorSlavic, Marija
dc.contributor.authorDjordjevic, Aleksandar
dc.contributor.authorRadojicic, Ratko
dc.contributor.authorMilovanovic, Slobodan
dc.contributor.authorOrescanin-Dusic, Zorana
dc.contributor.authorRakocevic, Zlatko
dc.contributor.authorSpasic, Mihajlo B.
dc.contributor.authorBlagojevic, Dusko
dc.date.accessioned2023-09-11T11:12:16Z
dc.date.available2023-09-11T11:12:16Z
dc.date.issued2013
dc.description.abstractDimethyl sulfoxide (DMSO) is a widely used solvent and cryoprotectant that can cause impaired blood flow, reduction in intracranial pressure, tissue edema, inflammatory reactions, inhibition of vascular smooth muscle cell migration and proliferation, processes which can lead to atherosclerosis of the coronary, peripheral and cerebral circulation. Although the adverse effects are rare when DMSO is administered in clinically established concentrations, there is no safe antagonist for an overdose. In this work, we treated isolated spontaneous and calciuminduced contractile active rat uteri (Wistar, virgo intacta), with DMSO and fullerenol C60(OH)24 nanoparticle (FNP) in DMSO. FNP is a water-soluble derivative of fullerene C60. Its size is a 1.1 nm in diameter and is a very promising candidate for a drug carrier in nanomedicine. FNP also displays free radical scavenging activity. DMSO decreased both spontaneous and calcium-induced contractions. In contrast, FNP only decreased spontaneous contraction. FNP decreased copper–zinc superoxide dismutase activity and prevented the DMSO-induced increase in glutathione reductase activity. Atomic force microscopy detected that FNP aggregated with calcium ions. Our results indicate that FNP has properties that make it a good candidate to be a modulator of DMSO activity which could minimize side effects of the latter.
dc.identifier.doi10.1007/s11051-013-1650-1
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/728
dc.language.isoen
dc.publisherSpringer
dc.sourceJournal of Nanoparticle Research
dc.subjectDMSO, Fullerenol C60(OH)24 nanoparticles, AFM, Uterus, SOD, Glutathione
dc.titleFullerenol C60(OH)24 nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction
dc.typeArticle
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