Protective effects of whey on rat liver damage induced by chronic alcohol intake

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dc.citation.epage645
dc.citation.spage632
dc.citation.volume38
dc.contributor.authorRadic, I.
dc.contributor.authorMijovic, M.
dc.contributor.authorTatalovic, N.
dc.contributor.authorMitic, M.
dc.contributor.authorLukic, V.
dc.contributor.authorJoksimovic, B.
dc.contributor.authorPetrovic, Z.
dc.contributor.authorRistic, S.
dc.contributor.authorVelickovic, S.
dc.contributor.authorNestorovic, V.
dc.contributor.authorCorac, A.
dc.contributor.authorMiric, M.
dc.contributor.authorAdzic, M.
dc.contributor.authorBlagojevic, DP
dc.contributor.authorPopovic, L.
dc.contributor.authorHudomal, SJ
dc.date.accessioned2023-07-11T12:49:33Z
dc.date.available2023-07-11T12:49:33Z
dc.date.issued2019
dc.description.abstractIn 2012, alcohol liver disease resulted in 3.3 million—5.9% of global deaths. This study introduced whey protection capacity against chronic alcohol-induced liver injury. Rats were orally administered to 12% ethanol solution in water (ad libitum, average 8.14 g of ethanol/kg body weight (b.w.)/day) alone or combined with whey (per os, 2 g/kg b.w./day). After 6-week treatment, chronic ethanol consumption induced significant histopathological liver changes: congestion, central vein dilation, hepatic portal vein branch dilation, Kupffer cells hyperplasia, fatty liver changes, and hepatocytes focal necrosis. Ethanol significantly increased liver catalase activity and glutathione reductase protein expression without significant effects on antioxidative enzymes: glutathione peroxidase (GPx), copper–zinc-containing superoxide dismutase (CuZnSOD) and manganesecontaining superoxide dismutase (MnSOD). Co-treatment with whey significantly attenuated pathohistological changes induced by ethanol ingestion and increased GSH-Px and nuclear factor kappa B (NF-kB) protein expression. Our results showed positive effects of whey on liver chronically exposed to ethanol, which seem to be associated with NF-kB-GPx signaling.
dc.identifier.doi10.1177/0960327119829518
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/422
dc.language.isoen
dc.publisherSAGE Publications
dc.sourceHuman and Experimental Toxicology
dc.subjectAlcohol liver disease, rat, whey, ethanol, antioxidant enzymes, NF-kB
dc.titleProtective effects of whey on rat liver damage induced by chronic alcohol intake
dc.typeArticle
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