INCREASED IL33 AND IL17 IN COLORECTAL CARCINOMA PATIENTS WITH SEVERE DISEASE

Једноставна страница ставке
dc.citation.epage245
dc.citation.spage239
dc.citation.volume21
dc.contributor.authorMaric, Veljko
dc.contributor.authorJovanovic, Milan
dc.contributor.authorZdravkovic, Natasa
dc.contributor.authorJovanovic, Marina
dc.contributor.authorGajovic, Nevena
dc.contributor.authorJurisevic, Milena
dc.contributor.authorJovanovic, Marina
dc.contributor.authorJovanovic, Ivan
dc.date.accessioned2023-07-03T11:34:54Z
dc.date.available2023-07-03T11:34:54Z
dc.date.issued2020
dc.description.abstractColorectal cancer (CRC) represents one of the most common cancers. It is frequently diagnosed at advanced stages, indicating on need for new diagnostic markers. The aim of this study was to determine systemic and fecal values of IL-17 and IL-33 in patients with CRC and the relationship with clinicopathological aspects of disease. The blood samples and feces liquid fraction of 50 patients with CRC were analyzed. Serum and fecal levels of IL-33 and IL-17 were measured using sensitive enzyme-linked immunosorbent assay (ELISA) kits. Fecal levels of Il-33 and IL-17 were increased in CRC patients with poor tumor tissue differentiation. Serum IL-33 and fecal IL-17 were increased in patients with presence of lung/liver metastasis or peritoneal carcinomatosis, respectively, while enhanced fecal IL-33 was detected only in patients with peritoneal carcinomatosis. Positive correlation between IL-33 and IL-17 values in sera and feces, respectively was also observed. We believe that increased local values of IL-33 and IL-17, reflected trough higher fecal concentration, in CRC patients with poor tumor tissue differentiation and with presence of lung/liver metastasis or peritoneal carcinomatosis may be considered as a sign of the tumor’s malignant progression and, consequently, of a poor prognosis for patients.
dc.identifier.doi10.2478/sjecr2018-0034
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/324
dc.language.isoen
dc.publisherSciendo
dc.sourceSerbian Journal of Experimental and Clinical Research
dc.subjectColorectal carcinoma, IL-17, IL-33.
dc.titleINCREASED IL33 AND IL17 IN COLORECTAL CARCINOMA PATIENTS WITH SEVERE DISEASE
dc.typeArticle
Датотеке
Оригинални завежљај
Сада се приказује 1 - 1 од 1
Сличица
Име:
INCREASED IL33 AND IL17 IN COLORECTAL CARCINOMA PATIENTS.pdf
Величина:
631.7 KB
Формат:
Adobe Portable Document Format
Опис:
Преузимање
Свежањ лиценце
Сада се приказује 1 - 1 од 1
Сличица
Име:
license.txt
Величина:
1.71 KB
Формат:
Item-specific license agreed to upon submission
Опис:
Преузимање
Колекције
Медицински факултет [Научни радови] / Faculty of Medicine [Scientific papers]