Ursodeoxycholic and chenodeoxycholic bile acids attenuate systemic and liver inflammation induced by lipopolysaccharide in rats

Једноставна страница ставке
dc.contributor.authorMilivojac, T.
dc.contributor.authorGrabež, M.
dc.contributor.authorKrivokuća, A.
dc.contributor.authorMaličević, U.
dc.contributor.authorGajić Bojić, M.
dc.contributor.authorĐukanović, Đ.
dc.contributor.authorUletilović, S.
dc.contributor.authorMandić-Kovačević, N.
dc.contributor.authorCvjetković, T.
dc.contributor.authorBarudžija, M.
dc.contributor.authorVojinović, N.
dc.contributor.authorŠmitran, A.
dc.contributor.authorAmidžić, LJ.
dc.contributor.authorStojiljković, M.P.
dc.contributor.authorČolić, M.
dc.contributor.authorMikov, M.
dc.contributor.authorŠkrbić, R.
dc.date.accessioned2024-11-14T08:01:04Z
dc.date.available2024-11-14T08:01:04Z
dc.date.issued2024
dc.description.abstractBacterial lipopolysaccharide (LPS) induces general inflammation, by activating pathways involving cytokine production, blood coagulation, complement system activation, and acute phase protein release. The key cellular players are leukocytes and endothelial cells, that lead to tissue injury and organ failure. The aim of this study was to explore the anti-inflammatory, antioxidant, and cytoprotective properties of two bile acids, ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) in LPS-induced endotoxemia in rats. The experiment involved six distinct groups of Wistar rats, each subjected to different pretreatment conditions: control and LPS groups were pretreated with propylene glycol, as a bile acid solvent, while the other groups were pretreated with UDCA or CDCA for 10 days followed by an LPS injection on day 10. The results showed that both UDCA and CDCA reduced the production of pro-inflammatory cytokines: TNF-α, GM-CSF, IL-2, IFNγ, IL-6, and IL-1β and expression of nuclear factor-κB (NF-κB) induced by LPS. In addition, pretreatment with these bile acids showed a positive impact on lipid profiles, a decrease in ICAM levels, an increase in antioxidant activity (SOD, |CAT, GSH), and a decrease in prooxidant markers (H2O2 and O2–). Furthermore, both bile acids alleviated LPS-induced liver injury. While UDCA and CDCA pretreatment attenuated homocysteine levels in LPS-treated rats, only UDCA pretreatment showed reductions in other serum biochemical markers, including creatine kinase, lactate dehydrogenase, and high-sensitivity troponin I. It can be concluded that both, UDCA and CDCA, although exerted slightly different effects, can prevent the inflammatory responses induced by LPS, improve oxidative stress status, and attenuate LPS-induced liver injury.
dc.identifier.doi10.1007/s11010-024-04994-2
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/1294
dc.language.isoen
dc.publisherSpringer
dc.sourceMolecular and Cellular Biochemistry
dc.subjectChenodeoxycholic acid · Ursodeoxycholic acid · Lipopolysaccharide · Endotoxemia · Oxidative stress · Inflammation
dc.titleUrsodeoxycholic and chenodeoxycholic bile acids attenuate systemic and liver inflammation induced by lipopolysaccharide in rats
dc.typeArticle
Датотеке
Оригинални завежљај
Сада се приказује 1 - 1 од 1
Сличица
Име:
Ursodeoxycholic and chenodeoxycholic bile acids attenuate systemic and liver inflammation induced by lipopolysaccharide in rats.pdf
Величина:
1.93 MB
Формат:
Adobe Portable Document Format
Опис:
Преузимање
Свежањ лиценце
Сада се приказује 1 - 1 од 1
Сличица
Име:
license.txt
Величина:
1.71 KB
Формат:
Item-specific license agreed to upon submission
Опис:
Преузимање
Колекције
Медицински факултет [Научни радови] / Faculty of Medicine [Scientific papers]