The Effect of Three-Month Vitamin D Supplementation on the Levels of Homocysteine Metabolism Markers and Inflammatory Cytokines in Sera of Psoriatic Patients

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dc.citation.spage1865
dc.citation.volume11
dc.contributor.authorPrtina, Alma
dc.contributor.authorRašeta Simović, Nela
dc.contributor.authorMilivojac, Tatjana
dc.contributor.authorVujnić, Milorad
dc.contributor.authorGrabež, Milkica
dc.contributor.authorDjuric, Dragan
dc.contributor.authorStojiljković, Miloš P.
dc.contributor.authorSoldat Stanković, Valentina
dc.contributor.authorČolić, Miodrag J.
dc.contributor.authorŠkrbić, Ranko
dc.date.accessioned2023-05-29T10:12:15Z
dc.date.available2023-05-29T10:12:15Z
dc.date.issued2021
dc.description.abstractPsoriasis is an autoimmune and inflammatory skin disease. Psoriatic patients express higher levels of plasma homocysteine (Hcy) concentration and pro-inflammatory mediators than healthy people; this is frequently associated with vitamin D deficiency. The aim of this clinical study was to investigate the effects of high doses of vitamin D supplementation on the parameters of Hcy metabolism and cytokines in sera of psoriatic patients. This prospective study was conducted on 40 psoriatic patients who had the vitamin D deficiency. All patients received vitamin D 5000 IU/day for three months. Clinical and biochemical measurements were taken at baseline and at follow up (3 months). The results showed that the severity of clinical features, measured by the psoriasis area severity index (PASI) score, were considerably improved in patients after vitamin D supplementation. After vitamin D supplementation, most of the patients (n = 25 or 62.5%) had mild clinical form (p < 0.001). After twelve weeks of intervention period, there were significant increases in vitamin D and B12 serum levels in comparison to the levels that had been measured at the beginning of the study (56.77 14.66 nmol/L and 301.08 95.02 pg/mL vs. 103.85 32.20 nmol/L and 362.81 118.56 pg/mL, respectively; p < 0.001). Moreover, serum levels of Hcy and folate were significantly lower at the end of the study in comparison with the initial levels (12.45 1.92 mol/L and 8.01 3.88 mg/mL vs. 10.38 1.66 mol/L and 6.27 2.60 mg/mL, respectively). High doses of vitamin D supplementation led to a significant decrease in pro-inflammatory cytokines (IFN-7, TNF- , IL-1 , IL-6, IL-8, and IL-17) and high-sensitivity C-reactive protein (hsCRP), whereas the production of anti-inflammatory cytokines (IL-10, IL-5) was up-regulated. In conclusion, supplementation with high doses of vitamin D could be one of the possible preventive and therapeutic measures to reduce systemic inflammation in psoriatic patients.
dc.identifier.doi10.3390/biom11121865
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/224
dc.language.isoen
dc.publisherMDPI
dc.sourceBiomolecules
dc.subjectpsoriasis; vitamin D supplementation; homocysteine; cytokine
dc.titleThe Effect of Three-Month Vitamin D Supplementation on the Levels of Homocysteine Metabolism Markers and Inflammatory Cytokines in Sera of Psoriatic Patients
dc.typeArticle
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