Moonlighting chromatin: when DNA escapes nuclear control

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dc.citation.epage875
dc.citation.spage861
dc.citation.volume30
dc.contributor.authorSingh, Jeeshan
dc.contributor.authorBoettcher, Michael
dc.contributor.authorDölling, Maximilian
dc.contributor.authorHeuer, Annika
dc.contributor.authorHohberger, Bettina
dc.contributor.authorLeppkes, Moritz
dc.contributor.authorNaschberger, Elisabeth
dc.contributor.authorSchapher, Mirco
dc.contributor.authorSchauer, Christine
dc.contributor.authorSchoen, Janina
dc.contributor.authorStürzl, Michael
dc.contributor.authorVitkov, Ljubomir
dc.contributor.authorWang, Han
dc.contributor.authorZlatar, Leticija
dc.contributor.authorSchett, Georg A.
dc.contributor.authorPisetsky, David S.
dc.contributor.authorLiu, Ming-Lin
dc.contributor.authorKnopf, Jasmin
dc.date.accessioned2024-12-06T12:32:41Z
dc.date.available2024-12-06T12:32:41Z
dc.date.issued2023
dc.description.abstractExtracellular chromatin, for example in the form of neutrophil extracellular traps (NETs), is an important element that propels the pathological progression of a plethora of diseases. DNA drives the interferon system, serves as autoantigen, and forms the extracellular scaffold for proteins of the innate immune system. An insufficient clearance of extruded chromatin after the release of DNA from the nucleus into the extracellular milieu can perform a secret task of moonlighting in immune-inflammatory and occlusive disorders. Here, we discuss (I) the cellular events involved in the extracellular release of chromatin and NET formation, (II) the devastating consequence of a dysregulated NET formation, and (III) the imbalance between NET formation and clearance. We include the role of NET formation in the occlusion of vessels and ducts, in lung disease, in autoimmune diseases, in chronic oral disorders, in cancer, in the formation of adhesions, and in traumatic spinal cord injury. To develop effective therapies, it is of utmost importance to target pathways that cause decondensation of chromatin during exaggerated NET formation and aggregation. Alternatively, therapies that support the clearance of extracellular chromatin are conceivable.
dc.identifier.doi10.1038/s41418-023-01124-1
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/1380
dc.language.isoen
dc.publisherSpringer
dc.sourceCell Death & Differentiation volume
dc.titleMoonlighting chromatin: when DNA escapes nuclear control
dc.typeArticle
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