Essential Oil of Satureja montana L. from Herzegovina: Assessment of Composition, Antispasmodic, and Antidiarrheal Effects

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dc.citation.epage548
dc.citation.spage536
dc.citation.volume17
dc.contributor.authorKulić, Milan
dc.contributor.authorDrakul, Dragana
dc.contributor.authorSokolović, Dragana
dc.contributor.authorKordić-Bojinović, Jelena
dc.contributor.authorMilovanović, Slobodan
dc.contributor.authorBlagojević, Duško
dc.date.accessioned2024-11-20T08:28:09Z
dc.date.available2024-11-20T08:28:09Z
dc.date.issued2023
dc.description.abstractSatureja montana L. (SM) has a long traditional use as a spice and a medicine for various gastrointestinal disorders, including painful spasms and diarrhea. Contrary to conventional drugs, administration of SM and its extracts are considered safe. Previous studies have shown that the essential oils (EOs) of SM from different areas are rich in monoterpenes, sesquiterpenes, diterpens, and phenolic compounds, including flavonoids, tannins, and acids with great composition variability. Determination of composition of EO from Herzegovinian SM done by gas chromatographyflame ionization detection and gas chromatography mass spectrometry (GC-FID and GC/MS, respectively) revealed carvacrol as a primary substance followed by γ-terpinene, p-cymene, and β-caryophyllene. Ex vivo spasmolitic activity caused by EO was evident in different types of isolated rat ileum function with the most potent effect on spontaneous activity followed by electrical field stimulation and KCl- and CaCl2-induced activity. SMEO produced in vivo antidiarreal activity on castor oil-induced diarrhea in young rats and showed the potential to cause a decrese water content in the feces of adult Wistar rats.This study indicates that effects of SM on the intestinum could be mediated through combination of Kv channel activation and Ca channel blockade, but additional mechanisms might be involved. The results of this study corroborate the traditional use of SM as antispasmodic, antidiarrheal, and antisecretory agents.
dc.identifier.doi10.25135/rnp.358.2207.2522
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/1317
dc.language.isoen
dc.publisherACG Publications
dc.sourceRecords of Natural Products
dc.subjectSatureja montana; antispasmodic; antidiarrheal. © 2022 ACG Publications. All rights reserved
dc.titleEssential Oil of Satureja montana L. from Herzegovina: Assessment of Composition, Antispasmodic, and Antidiarrheal Effects
dc.typeArticle
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