The Impact of Cytokines on Coagulation Profile in COVID-19 Patients: Controlled for Socio-Demographic, Clinical, and Laboratory Parameters

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dc.citation.spage1281
dc.citation.volume12
dc.contributor.authorMilentijević, Milica
dc.contributor.authorKatanić, Nataša
dc.contributor.authorJoksimović, Bojan
dc.contributor.authorPavlović, Aleksandar
dc.contributor.authorFilimonović, Jelena
dc.contributor.authorAnđelković, Milena
dc.contributor.authorBojović, Ksenija
dc.contributor.authorElek, Zlatan
dc.contributor.authorRistić, Siniša
dc.contributor.authorVasiljević, Miloš
dc.contributor.authorStevanović, Jasmina
dc.contributor.authorRadomirović, Danica
dc.contributor.authorElez-Burnjaković, Nikolina
dc.contributor.authorLalović, Nenad
dc.contributor.authorKulić, Milan
dc.contributor.authorKulić, Jovan
dc.contributor.authorMilić, Marija
dc.date.accessioned2024-11-07T12:35:59Z
dc.date.available2024-11-07T12:35:59Z
dc.date.issued2024
dc.description.abstractSevere coagulation abnormalities are common in patients with COVID-19 infection. We aimed to investigate the relationship between pro-inflammatory cytokines and coagulation parameters concerning socio-demographic, clinical, and laboratory characteristics. Methods: Our study included patients hospitalized during the second wave of COVID-19 in the Republic of Serbia. We collected socio-demographic, clinical, and blood-sample data for all patients. Cytokine levels were measured using flow cytometry. Results: We analyzed data from 113 COVID-19 patients with an average age of 58.15 years, of whom 79 (69.9%) were male. Longer duration of COVID-19 symptoms before hospitalization (B = 69.672; p = 0.002) and use of meropenem (B = 1237.220; p = 0.014) were predictive of higher D-dimer values. Among cytokines, higher IL-5 values significantly predicted higher INR values (B = 0.152; p = 0.040) and longer prothrombin times (B = 0.412; p = 0.043), and higher IL-6 (B = 0.137; p = 0.003) predicted longer prothrombin times. Lower IL-17F concentrations at admission (B = 0.024; p = 0.050) were predictive of higher INR values, and lower IFN-γ values (B = −0.306; p = 0.017) were predictive of higher aPTT values. Conclusions: Our findings indicate a significant correlation between pro-inflammatory cytokines and coagulation-related parameters. Factors such as the patient’s level of education, gender, oxygen-therapy use, symptom duration before hospitalization, meropenem use, and serum concentrations of IL-5, IL-6, IL-17F, and IFN-γ were associated with worse coagulation-related parameters.
dc.identifier.doi10.3390/biomedicines12061281
dc.identifier.urihttps://vaseljena.ues.rs.ba/handle/123456789/1254
dc.language.isoen
dc.publisherMDPI
dc.sourceBiomedicines
dc.subjectCOVID-19; cytokines; coagulation parameters; D-dimer; fibrinogen; aPTT
dc.titleThe Impact of Cytokines on Coagulation Profile in COVID-19 Patients: Controlled for Socio-Demographic, Clinical, and Laboratory Parameters
dc.typeArticle
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